Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity

被引：20

作者：

Palada, Vinko ^{[1
]}

Ahmed, Aisha Siddiqah ^{[2
]}

Freyhult, Eva ^{[3
]}

Hugo, Anders ^{[4
]}

Kultima, Kim ^{[1
,3
]}

Svensson, Camilla I. ^{[1
]}

Kosek, Eva ^{[2
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden

[3] Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden

[4] Ortho Ctr Stockholm, S-19489 Upplands Vasby, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 349卷

基金：

瑞典研究理事会;

关键词：

Osteoarthritis (OA); Knee pain; Neuroinflammation; Proximity extension assay (PEA); Cerebrospinal fluid; Serum; Cytokines; Chemokines; BLOOD-BRAIN-BARRIER; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SYNOVIAL-FLUID; MECHANICAL STIMULI; CYTOKINE LEVELS; RECEPTOR; SYSTEM; SENSITIZATION; INTERLEUKIN-8; FIBROMYALGIA;

D O I：

10.1016/j.jneuroim.2020.577391

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation and periphery-to-CNS neuroimmune cross-talk in patients with painful knee osteoarthritis (OA) are poorly understood. We utilized proximity extension assay to measure the level of 91 inflammatory proteins in CSF and serum from OA patients and controls. The patients had elevated levels of 48 proteins in CSF indicating neuroinflammation. Ten proteins were correlated between CSF and serum and potentially involved in periphery-to-CNS neuroimmune cross-talk. Seven CSF proteins, all with previously reported neuroprotective effects, were associated with lower pain intensity and milder knee-related symptoms. Our findings indicate that neuroinflammation in OA could be protective and associated with less severe symptoms.

引用

页数：11

共 50 条

[21] Elevated plasma and synovial fluid interleukin-8 and interleukin-18 may be associated with the pathogenesis of knee osteoarthritis [J].

Koh, S. M. ;

Chan, C. K. ;

Teo, S. H. ;

Singh, S. ;

Merican, A. ;

Ng, W. M. ;

Abbas, A. ;

Kamarul, T. .

KNEE, 2020, 27 (01) :26-35

[22] Pain sensitization and degenerative changes are associated with aberrant plantar loading in patients with painful knee osteoarthritis [J].

Rosland, T. ;

Gregersen, L. S. ;

Eskehave, T. N. ;

Kersting, U. G. ;

Arendt-Nielsen, L. .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2015, 44 (01) :61-69

[23] The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis [J].

Struglics, Andre ;

Okroj, Marcin ;

Sward, Per ;

Frobell, Richard ;

Saxne, Tore ;

Lohmander, L. Stefan ;

Blom, Anna M. .

ARTHRITIS RESEARCH & THERAPY, 2016, 18

[24] Cerebrospinal fluid glutamate inversely correlates with positive symptom severity in unmedicated male schizophrenic/schizoaffective patients [J].

Faustman, WO ;

Bardgett, M ;

Faull, KF ;

Pfefferbaum, A ;

Csernansky, JG .

BIOLOGICAL PSYCHIATRY, 1999, 45 (01) :68-75

[25] Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion [J].

Calvet, Joan ;

Orellana, Cristobal ;

Gratacos, Jordi ;

Berenguer-Llergo, Antoni ;

Caixas, Assumpta ;

Jose Chillaron, Juan ;

Pedro-Botet, Juan ;

Garcia-Manrique, Maria ;

Navarro, Noemi ;

Larrosa, Marta .

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[26] Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion [J].

Joan Calvet ;

Cristóbal Orellana ;

Jordi Gratacós ;

Antoni Berenguer-Llergo ;

Assumpta Caixàs ;

Juan José Chillarón ;

Juan Pedro-Botet ;

María García-Manrique ;

Noemí Navarro ;

Marta Larrosa .

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[27] S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis [J].

Wang, Li-chun ;

Zhang, Hong-ying ;

Shao, Lin ;

Chen, Lin ;

Liu, Ze-han ;

He, Xu ;

Gong, Wei-xun .

BIOMARKERS, 2013, 18 (03) :216-220

[28] Dimethylarginine Levels in Cerebrospinal Fluid of Hyperacute Ischemic Stroke Patients are Associated with Stroke Severity [J].

Brouns, Raf ;

Marescau, Bart ;

Possemiers, Ilse ;

Sheorajpanday, Rishi ;

De Deyn, Peter P. .

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[29] Dimethylarginine Levels in Cerebrospinal Fluid of Hyperacute Ischemic Stroke Patients are Associated with Stroke Severity [J].

Raf Brouns ;

Bart Marescau ;

Ilse Possemiers ;

Rishi Sheorajpanday ;

Peter P. De Deyn .

Neurochemical Research, 2009, 34 :1642-1649

[30] Decreased pain sensitivity and alterations of cerebrospinal fluid and plasma inflammatory mediators after total hip arthroplasty in patients with disabling osteoarthritis [J].

Bjurstrom, Martin F. ;

Bodelsson, Mikael ;

Irwin, Michael R. ;

Orbjorn, Camilla ;

Hansson, Oskar ;

Mattsson-Carlgren, Niklas .

PAIN PRACTICE, 2022, 22 (01) :66-82

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