SYNTHESIS AND PHARMACOLOGICAL SCREENING OF NEW ISATIN-3-[N2-(BENZIMIDAZOL-1-ACETYL)]HYDRAZONE

被引：4

作者：

Chaithanya, B. ^{[1
]}

Kasiviswanath, I., V ^{[1
]}

Chary, D. Prabhakara ^{[2
]}

机构：

[1] Koneru Lakshmaiah Educ Fdn, Dept Chem, Green Fields, Vaddeswaram 522502, Guntur, India

[2] Kakatiya Inst Technol & Sci, Dept Phys Sci, Warangal, Andhra Pradesh, India

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2019年 / 33卷 / 02期

关键词：

Antibacterial activity; Antifungal activity; Antioxidant activity; Cytotoxic activity; Benzimidazole; Isatin; BENZIMIDAZOLE DERIVATIVES; ANTIFUNGAL; ISATIN;

D O I：

10.4314/bcse.v33i2.12

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Twenty new isatin-3[N-2-(benzimidazol-l-acetyl)]hydrazones (IV) were synthesized from ten different isatin-3-[N-2-(chloroacetyl)] hydrazones (III) by reacting with benzimidazole and 2-methyl benzimidazole. The intermediates were obtained from isatin hydrazones (II) on condensation with chloroacetyl chloride. These compounds were characterized by IR, H-1 NMR and mass spectra. All the compounds were screened for antimicrobial, antioxidant and cytotoxic activity. Some of the new compounds showed promising antibacterial and antifungal activity.

引用

页码：321 / 329

页数：9

共 23 条

[1] SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME NOVEL MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES [J].

Ahmadi, A. .

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2016, 30 (03) :421-425

[2] PYRIDINIUM AZOLATE BETAINES AND THEIR DERIVATIVES - A NEW CLASS OF ANTIPROTOZOAL AGENTS [J].

ALCALDE, E ;

DINARES, I ;

ELGUERO, J ;

FRIGOLA, J ;

OSUNA, A ;

CASTANYS, S .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1990, 25 (04) :309-319

[3]

Alpan A. S., 2017, ARCH PHARM WEINHEIM, V350, P1

[4]

Bhatt AK, 2004, INDIAN J HETEROCY CH, V13, P281

[5] Some characteristics of activity of potential chemotherapeutics - benzimidazole derivatives [J].

Blaszczak-Swiatkiewicz, Katarzyna ;

Mikiciuk-Olasik, Elibieta .

ADVANCES IN MEDICAL SCIENCES, 2015, 60 (01) :125-132

[6] Synthesis and investigation of novel benzimidazole derivatives as antifungal agents [J].

Chandrika, Nishad Thamban ;

Shrestha, Sanjib K. ;

Ngo, Huy X. ;

Garneau-Tsodikova, Sylvie .

BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (16) :3680-3686

[7]

Gummadi S.B., 2010, Der Pharma Chemica, V2, P196

[8] Isatin derivatives and their anti-bacterial activities [J].

Guo, Hua .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 164 :678-688

[9]

HABIB NS, 1989, FARMACO, V44, P1225

[10] Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives [J].

Jarrahpour, Aliasghar ;

Khalili, Dariush ;

De Clercq, Erik ;

Salmi, Chanaz ;

Brunel, Jean Michel .

MOLECULES, 2007, 12 (08) :1720-1730

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