Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment JACC Focus Seminar

被引：70

作者：

Jenkins, David J. A. ^{[1
,2
,3
,4
,5
]}

Spence, J. David ^{[6
]}

Giovannucci, Edward L. ^{[7
,8
]}

Kim, Young-in ^{[1
,9
,10
]}

Josse, Robert G. ^{[1
,2
,5
]}

Vieth, Reinhold ^{[1
]}

Sahye-Pudaruth, Sandhya ^{[1
,4
]}

Paquette, Melanie ^{[1
,4
]}

Patel, Darshna ^{[1
,4
]}

Mejia, Sonia Blanco ^{[1
,3
,4
]}

Viguiliouk, Effie ^{[1
,3
,4
]}

Nishi, Stephanie K. ^{[1
,3
,4
]}

Kavanagh, Meaghan ^{[1
,4
]}

Tsirakis, Tom ^{[4
]}

Kendall, Cyril W. C. Kendall ^{[1
,3
,4
,11
]}

Pichika, Sathish C. ^{[1
,12
]}

Sievenpiper, John L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Temerty, Toronto, ON, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[3] St Michaels Hosp, Toronto 3D Knowledge Synth & Clin Trials Unit, Toronto, ON, Canada

[4] St Michaels Hosp, Clin Nutr Risk Factor Modificat Ctr, Toronto, ON, Canada

[5] St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON, Canada

[6] Western Univ, Robarts Res Inst, Stroke Prevent & Aherosclerosis Res Ctr, London, ON, Canada

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[8] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[9] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada

[10] St Michaels Hosp, Div Gastroenterol, Toronto, ON, Canada

[11] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada

[12] Univ Windsor, Dept Math & Stat, Windsor, ON, Canada

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2021年 / 77卷 / 04期

基金：

加拿大健康研究院; 加拿大创新基金会;

关键词：

all-cause mortality; cardiovascular disease; meta-analysis; supplements; FOLIC-ACID SUPPLEMENTATION; EXTENDED-RELEASE NIACIN; STAGE RENAL-DISEASE; MYOCARDIAL-INFARCTION; B-VITAMINS; CANCER INCIDENCE; PROSTATE-CANCER; TOTAL MORTALITY; HIGH-RISK; HOMOCYSTEINE;

D O I：

10.1016/j.jacc.2020.09.619

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled trials and meta-analyses were identified by searching the Cochrane library, Medline, and Embase, and data were analyzed using random effects models and classified by the Grading of Recommendations Assessment Development and Evaluation approach. This updated review shows similar findings to the previous report for preventive benefits from both folic acid and B vitamins for stroke and has been graded with moderate quality. No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated. (C) 2021 Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：423 / 436

页数：14

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