A tunable high-frequency operational transconductance amplifier (OTA) is presented along with its application in the implementation of a Gm-C filter. The OTA is tuned by varying the negative resistance produced by a positive feedback at the output. Post-layout simulation results (using TSMC 90 nm CMOS technology and a 1-V supply voltage) show that the differential DC gain, common-mode gain and OTA unity gain frequency are 34 dB, -26 dB and 10 GHz, respectively. Moreover, for precise control of filter performance, an auto-tuning circuit is presented to adjust the filter cutoff frequency at low power consumption (i.e., 0.6 mW, about 16.3% of the total circuit power consumption). The filter has a cutoff frequency of 1 GHz with a group delay variation less than 6% up to 1.3 f(c). The size of filter is 0.040 x 0.023mm(2) and the third order intermodulation (IM3) value at cutoff frequency is -37 dB. The Monte Carlo simulation results are presented for predicting the manufacturing process errors.