Depth profiling of 4-acetamindophenol-doped poly(lactic acid) films using cluster secondary ion mass spectrometry

被引:123
作者
Mahoney, CM [1 ]
Roberson, SV [1 ]
Gillen, G [1 ]
机构
[1] NIST, Chem Sci & Technol Lab, Surface & Microanal Sci Div, Gaithersburg, MD 20899 USA
关键词
D O I
10.1021/ac035532n
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The feasibility of using cluster secondary ion mass spectrometry for depth profiling of drug delivery systems is explored. The behavior of various biodegradable polymer films under dynamic SF5+ primary ion bombardment was investigated, including several films doped with model drugs. The SF5+ depth profiles obtained from these biodegradable polymer films showed very little degradation in secondary ion signal as a function of increasing primary ion dose, and it was discovered that the characteristic ion signals for the polymers remained constant for ion doses up to similar to5 x 10(15) ions/cm(2). These results suggest that the polyester structure of the biodegradable polymers studied here allows for a greater ability to depth profile due to ease of main chain scission. Attempts were also made to depth profile through a series of poly(lactic acid) (PLA) films containing varying concentrations of the drug 4-acetamidophenol. The depth profiles obtained from these films show very little decrease in both the 4-acetamidophenol molecular ion and PLA fragment ion signals as a function of increasing SF5+ primary ion dose. Similar results were obtained with theophylline-doped PLA films. These results show that, in some drug delivery devices, it is possible to monitor the distribution of a drug as a function of depth by using cluster primary ion beams.
引用
收藏
页码:3199 / 3207
页数:9
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