Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease:: A population-based study of African Americans

被引：182
作者：
Evans, RM
Emsley, CL
Gao, S
Sahota, A
Hall, KS
Farlow, MR
Hendrie, H
机构：
[1] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
[3] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA
[4] Rutgers State Univ, Dept Genet, New Brunswick, NJ 08903 USA
来源：
NEUROLOGY | 2000年 / 54卷 / 01期
关键词：
cholesterol; APOE genotype; AD; African American;
D O I：
10.1212/WNL.54.1.240
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no epsilon 4 alleles, whereas TC was not associated with increased AD risk in the group with one or more epsilon 4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.
引用
收藏
页码：240 / 242
页数：3
相关论文
共 11 条
[1]   LIPOPROTEIN-CHOLESTEROL ANALYSIS DURING SCREENING - ACCURACY AND RELIABILITY [J].
BACHORIK, PS ;
CLOEY, TA ;
FINNEY, CA ;
LOWRY, DR ;
BECKER, DM .
ANNALS OF INTERNAL MEDICINE, 1991, 114 (09) :741-747
[2]  
Hall KS, 1996, INT J METHOD PSYCH, V6, P129, DOI 10.1002/(SICI)1234-988X(199610)6:3<129::AID-MPR164>3.3.CO
[3]  
2-A
[4]  
HENDRIE HC, 1995, AM J PSYCHIAT, V152, P1485
[5]  
HIXON JE, 1990, J LIPID RES, V31, P545
[6]   INTERACTIONS OF APOLIPOPROTEIN-E GENOTYPE, TOTAL CHOLESTEROL LEVEL, AGE, AND SEX IN PREDICTION OF ALZHEIMERS-DISEASE - A CASE-CONTROL STUDY [J].
JARVIK, GP ;
WIJSMAN, EM ;
KUKULL, WA ;
SCHELLENBERG, GD ;
YU, C ;
LARSON, EB .
NEUROLOGY, 1995, 45 (06) :1092-1096
[7]   Serum total cholesterol, apolipoprotein E ε4 allele, and Alzheimer's disease [J].
Notkola, IL ;
Sulkava, R ;
Pekkanen, J ;
Erkinjuntti, T ;
Ehnholm, C ;
Kivinen, P ;
Tuomilehto, A ;
Nissinen, A .
NEUROEPIDEMIOLOGY, 1998, 17 (01) :14-20
[8]   LACK OF AN ASSOCIATION BETWEEN APOLIPOPROTEIN-E EPSILON-4 AND ALZHEIMERS-DISEASE IN ELDERLY NIGERIANS [J].
OSUNTOKUN, BO ;
SAHOTA, A ;
OGUNNIYI, AO ;
GUREJE, O ;
BAIYEWU, O ;
ADEYINKA, A ;
OLUWOLE, SO ;
KOMOLAFE, O ;
HALL, KS ;
UNVERZAGT, FW ;
HUI, SL ;
YANG, M ;
HENDRIE, HC .
ANNALS OF NEUROLOGY, 1995, 38 (03) :463-465
[9]   APOLIPOPROTEIN-E AND ALZHEIMER-DISEASE [J].
STRITTMATTER, WJ ;
ROSES, AD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4725-4727
[10]  
Tang MX, 1996, AM J HUM GENET, V58, P574
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