In-vitro investigation of the hemodynamic responses of the cerebral, coronary and renal circulations with a rotary blood pump installed in the descending aorta
被引:8
作者:
Rezaienia, M. A.
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Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Rezaienia, M. A.
[1
]
Paul, G.
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Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Paul, G.
[1
]
Avital, E. J.
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Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Avital, E. J.
[1
]
Mozafari, S.
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Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Mozafari, S.
[1
]
Rothman, M.
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Barts & London NHS Trust, London Chest Hosp, Dept Cardiol, London E2 9JX, EnglandQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Rothman, M.
[2
]
Korakianitis, T.
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St Louis Univ, Pk Coll Engn Aviat & Technol, St Louis, MO 63103 USAQueen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Korakianitis, T.
[3
]
机构:
[1] Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
[2] Barts & London NHS Trust, London Chest Hosp, Dept Cardiol, London E2 9JX, England
[3] St Louis Univ, Pk Coll Engn Aviat & Technol, St Louis, MO 63103 USA
This study investigates the hemodynamic responses of the cardiovascular system when a rotary blood pump is operating in the descending aorta, with a focus on the cerebral, coronary and renal autoregulation, using our in-house cardiovascular emulator. Several improvements have been made from our previous studies. A novel coronary system was developed to replicate the native coronary perfusion. Three pinch valves actuated by stepper motors were used to simulate the regional autoregulation systems of the native cerebral, coronary and renal circulations. A rotary pump was installed in the descending aorta, in series with the heart, and the hemodynamic responses of the cardiovascular system were investigated with a focus on cerebral, coronary and renal circulation over a wide range of pump rotor speeds. Experiments were performed twice, once with the autoregulation systems active and once with the autoregulation systems inactive, to reflect that there will be some impairment of autoregulatory systems in a patient with heart failure. It was shown that by increasing the rotor speed to 3000 rpm, the cardiac output was improved from 2.9 to 4.1 L/min as a result of an afterload reduction induced by the pressure drop upstream of the pump. The magnitudes of changes in perfusion in the cerebral, coronary and renal circulations were recorded with regional autoregulation systems active and inactive. (C) 2016 Published by Elsevier Ltd on behalf of IPEM.
机构:
Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Dept Vet Affairs Med Ctr, Gainesville, FL USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Denardo, Scott J.
Nandyala, Ramavathi
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机构:
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Nandyala, Ramavathi
Freeman, Gregory L.
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机构:
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Freeman, Gregory L.
Pierce, Gary L.
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机构:
Univ Colorado, Boulder, CO 80309 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Pierce, Gary L.
Nichols, Wilmer W.
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机构:Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
机构:
Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, CanadaUniv Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Ford, MD
Alperin, N
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机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Alperin, N
Lee, SH
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机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Lee, SH
Holdsworth, DW
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机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Holdsworth, DW
Steinman, DA
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h-index: 0
机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
机构:
Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Dept Vet Affairs Med Ctr, Gainesville, FL USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Denardo, Scott J.
Nandyala, Ramavathi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Nandyala, Ramavathi
Freeman, Gregory L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Freeman, Gregory L.
Pierce, Gary L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Boulder, CO 80309 USAUniv Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
Pierce, Gary L.
Nichols, Wilmer W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32610 USA
机构:
Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, CanadaUniv Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Ford, MD
Alperin, N
论文数: 0引用数: 0
h-index: 0
机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Alperin, N
Lee, SH
论文数: 0引用数: 0
h-index: 0
机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Lee, SH
Holdsworth, DW
论文数: 0引用数: 0
h-index: 0
机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada
Holdsworth, DW
Steinman, DA
论文数: 0引用数: 0
h-index: 0
机构:Univ Western Ontario, Imaging Res Labs, Robarts Res Inst, London, ON, Canada