In-vitro investigation of the hemodynamic responses of the cerebral, coronary and renal circulations with a rotary blood pump installed in the descending aorta

被引:8
作者
Rezaienia, M. A. [1 ]
Paul, G. [1 ]
Avital, E. J. [1 ]
Mozafari, S. [1 ]
Rothman, M. [2 ]
Korakianitis, T. [3 ]
机构
[1] Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
[2] Barts & London NHS Trust, London Chest Hosp, Dept Cardiol, London E2 9JX, England
[3] St Louis Univ, Pk Coll Engn Aviat & Technol, St Louis, MO 63103 USA
基金
美国国家卫生研究院;
关键词
Cardiovascular simulator; Blood pump; MCS; RBP; VAD; HEART-FAILURE; SUPPORT DEVICE; FLOW; PULSATILE; PERFUSION; AUTOREGULATION; PRESSURE; SYSTEM;
D O I
10.1016/j.medengphy.2016.11.006
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study investigates the hemodynamic responses of the cardiovascular system when a rotary blood pump is operating in the descending aorta, with a focus on the cerebral, coronary and renal autoregulation, using our in-house cardiovascular emulator. Several improvements have been made from our previous studies. A novel coronary system was developed to replicate the native coronary perfusion. Three pinch valves actuated by stepper motors were used to simulate the regional autoregulation systems of the native cerebral, coronary and renal circulations. A rotary pump was installed in the descending aorta, in series with the heart, and the hemodynamic responses of the cardiovascular system were investigated with a focus on cerebral, coronary and renal circulation over a wide range of pump rotor speeds. Experiments were performed twice, once with the autoregulation systems active and once with the autoregulation systems inactive, to reflect that there will be some impairment of autoregulatory systems in a patient with heart failure. It was shown that by increasing the rotor speed to 3000 rpm, the cardiac output was improved from 2.9 to 4.1 L/min as a result of an afterload reduction induced by the pressure drop upstream of the pump. The magnitudes of changes in perfusion in the cerebral, coronary and renal circulations were recorded with regional autoregulation systems active and inactive. (C) 2016 Published by Elsevier Ltd on behalf of IPEM.
引用
收藏
页码:2 / 10
页数:9
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