Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

被引：17
作者：
Chen, Zhen
Chen, Pan
Wu, Hao
Shi, Rui
Su, Weiwei
Wang, Yonggang
Li, Peibo [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Life Sci, Guangdong Engn & Technol Res Ctr Qual & Efficacy, State Key Lab Biocontrol, Guangzhou 510275, Peoples R China
来源：
BIOMOLECULES | 2020年 / 10卷 / 12期
关键词：
COPD; naringenin; pathogenesis; mechanism; OBSTRUCTIVE PULMONARY-DISEASE; ACUTE LUNG INJURY; NF-KAPPA-B; GUINEA-PIG MODEL; THYMIC STROMAL LYMPHOPOIETIN; INDUCED AIRWAY INFLAMMATION; EXPIRED BREATH CONDENSATE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; INDUCED COUGH;
D O I：
10.3390/biom10121644
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.
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页码：1 / 29
页数：29
相关论文
共 144 条
[1]   Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD) [J].
Agarwal, Amit R. ;
Kadam, Smita ;
Brahme, Ankita ;
Agrawal, Manas ;
Apte, Komalkirti ;
Narke, Govinda ;
Kekan, Kushal ;
Madas, Sapna ;
Salvi, Sundeep .
RESPIRATORY RESEARCH, 2019, 20 (1)
[2]   Naringin Attenuates the Development of Carrageenan-Induced Acute Lung Inflammation Through Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-Inflammatory Cytokines [J].
Ahmad, Sheikh Fayaz ;
Attia, Sabry M. ;
Bakheet, Saleh A. ;
Zoheir, Khairy M. A. ;
Ansari, Mushtaq Ahmad ;
Korashy, Hesham M. ;
Abdel-Hamied, Hala E. ;
Ashour, Abdelkader E. ;
Abd-Allah, Adel R. A. .
INFLAMMATION, 2015, 38 (02) :846-857
[3]   Naringenin adds to the protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats: Favorable modulation of oxidative stress, inflammation and nitric oxide [J].
Ahmed, Lamiaa A. ;
Obaid, Al Arqam Z. ;
Zaki, Hala F. ;
Agha, Azza M. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 62 :161-170
[4]   Potential Protective Effects of Naringin on Oculo-Pulmonary Injury Induced by PM10 (Wood Smoke) Exposure by Modulation of Oxidative Damage and Acetylcholine Esterase Activity in a Rat Model [J].
Akintunde, Jacob K. ;
Abioye, Joseph B. ;
Ebinama, Owen N. .
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2020, 92
[5]   Amelioration of Benzo[a]pyrene-induced oxidative stress and pulmonary toxicity by Naringenin in Wistar rats: A plausible role of COX-2 and NF-κB [J].
Ali, R. ;
Shahid, A. ;
Ali, N. ;
Hasan, S. K. ;
Majed, F. ;
Sultana, S. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2017, 36 (04) :349-364
[6]   The 3 major types of innate and adaptive cell-mediated effector immunity [J].
Annunziato, Francesco ;
Romagnani, Chiara ;
Romagnani, Sergio .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (03) :626-635
[7]   Monitoring Antioxidant Enzyme Activity during Exacerbations of Chronic Obstructive Pulmonary Disease [J].
Antus, Balazs ;
Paska, Csilla ;
Simon, Beatrix ;
Barta, Imre .
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2018, 15 (05) :496-502
[8]   Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPD [J].
Arif, Ehtesham ;
Ahsan, Aarif ;
Vibhuti, Arpana ;
Rajput, Charu ;
Deepak, Desh ;
Athar, Mohammad ;
Singh, Bhawani ;
Pasha, M. A. Qadar .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) :182-188
[9]   Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species [J].
Bai, Yang ;
Peng, Wei ;
Yang, Cuiping ;
Zou, Wei ;
Liu, Menghua ;
Wu, Hao ;
Fan, Loudi ;
Li, Peibo ;
Zeng, Xuan ;
Su, Weiwei .
FRONTIERS IN PHARMACOLOGY, 2020, 11
[10]   Vascular Biomarkers in Asthma and COPD [J].
Bakakos, Petros ;
Patentalakis, George ;
Papi, Alberto .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 16 (14) :1599-1609
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