N-Hydroxypyridone alkaloids, chromone derivatives, and. tetrahydroxanthones from the scale-insect pathogenic fungus Orbiocrella sp BCC 33248

被引：15

作者：

Isaka, Masahiko ^{[1
]}

Haritakun, Rachada ^{[1
]}

Supothina, Sumalee ^{[1
]}

Choowong, Wilunda ^{[1
]}

Mongkolsamrit, Suchada ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klongluang 12120, Pathumthani, Thailand

来源：

TETRAHEDRON | 2014年 / 70卷 / 48期

关键词：

Orbiocrella; Invertebrate pathogenic fungi; Antimalarial activity; Cytotoxicity;

D O I：

10.1016/j.tet.2014.10.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six new compounds, an N-hydroxypyridone glucoside, orbiocrellin A (1), its aglycone orbiocrellin B (2), chromone glucosides 3 and 4, a dihydrochromone 5a/5b, and a chromone 6, were isolated from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248. Orbiocrellin A (1) exhibited antimalarial activity against Plasmodium falciparum K1 (IC50 3.1 mu g/mL) while it was non-cytotoxic. In contrast, orbiocrellin B (2) showed both antimalarial (IC50 2.1 mu g/mL) and cytotoxic (NCI-H187 cells, IC50 0.70 mu g/mL) activities. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：9198 / 9203

页数：6

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