The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease

被引:51
作者
Devier, Deidre J. [1 ]
Pelton, Gregory H. [2 ,3 ,4 ]
Tabert, Matthias H. [2 ,3 ,4 ]
Liu, Xinhua [2 ,3 ,4 ]
Cuasay, Katrina [2 ,3 ,4 ]
Eisenstadt, Rachel [2 ,3 ,4 ]
Marder, Karen [2 ,3 ,4 ]
Stern, Yaakov [2 ,3 ,4 ]
Devanand, D. P. [2 ,3 ,4 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Neurol, New Orleans, LA 70112 USA
[2] Taub Inst, Dept Neurol, Sergievsky Ctr, New York, NY USA
[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[4] Columbia Univ, Coll Phys & Surg, New York, NY USA
关键词
mild cognitive impairment; Alzheimer's disease; anxiety; depression; SYMPTOMS; DEMENTIA; PROGRESSION; DEPRESSION; PREDICTION; DISORDERS; DECLINE; SCALE; RISK;
D O I
10.1002/gps.2263
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective To compare state and trait anxiety in mild cognitive impairment (MCI) patients and matched control subjects, and to assess the impact of these variables in predicting conversion to Alzheimer's disease. Methods One hundred and forty-eight patients with MCI, broadly defined, were assessed and followed systematically. Baseline predictors for follow-up conversion to AD (entire sample: 39/148 converted to Alzheimer's disease (AD)) included the Spielberger State-Trait Anxiety Inventory (STAI). Results At baseline evaluation. MCI patients had higher levels of state and trait anxiety than controls, with no differences between future AD converters (n = 39) and non-converters. In age-stratified Cox proportional hazards model analyses, STAI State was not a significant predictor of conversion to AD (STAI State <= 30 vs. > 30 risk ratio, 1.68; 95% Cl, 0.75, 3.77; p=0.21), but higher Trait scores indicated a lower risk of conversion when STAI State, education, the Folstein Mini-Mental State Examination and HAM-D (depression score) were also included in the model (STAI Trait <= 30 vs. > 30 risk ratio, 0.36; 95%a CI, 0.16, 0.82; p=0.015). Conclusions In contrast to two other recent studies that showed anxiety predicted cognitive decline or conversion to AD, in this clinic-based sample, state anxiety was not a significant predictor. However, higher Trait anxiety predicted a lower risk of future conversion to AD. Further research with systematic long-term follow-tip in larger samples is needed to clarify the role of state and trait anxiety in predicting MCI conversion to AD. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:1335 / 1342
页数:8
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