Effect of hepatocyte growth factor on cell cycle and c-met expression in human gastric cancer cells

被引：0
作者：
Liu, SI
Lui, WY
Mok, KT
Wu, CW
Chi, CW
机构：
[1] VET GEN HOSP,DEPT MED RES,TAIPEI 11217,TAIWAN
[2] VET GEN HOSP,DEPT SURG,TAIPEI 11217,TAIWAN
[3] NATL YANG MING UNIV,INST CLIN MED,TAIPEI 11217,TAIWAN
[4] VET GEN HOSP,DEPT SURG,KAOHSIUNG 813,TAIWAN
来源：
ANTICANCER RESEARCH | 1997年 / 17卷 / 5A期
关键词：
hepatocyte growth factor; protooncogene c-met; gastric cancer; cell cycle; flow cytometry;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocyte growth factor (HGF) was found to stimulate the growth and progression of gastric cancer cells through hepatocyte growth factor receptor (HGFR). In the present study, the effects of HGF on the expression of HGFR in relation to cell cycle progression of human gastric cancer cells were investigated by two-parameter flow cytometric analysis. We found that the expression of HGFR in SC-Ml and KATO-III gastric cancer cells was cycle dependent, the level of HGFR increased front GO-Gl to S phase and the highest level of HGFR was found in G2-M phases. The level of HGFR was higher in KATO-III than SC-Ml cells. However, HGF treatment induced a dose-dependent stimulation of growth as well as down-regulation of HGFR in SC-Ml cells but not in KATO-III cells. These results suggest that functional HGFR rather than overexpressed HGFR may be more important for the growth of gastric cancer cells.
引用
收藏
页码：3575 / 3580
页数：6
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