Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

被引：30

作者：

Plastina, Pierluigi ^{[1
]}

Meijerink, Jocelijn ^{[1
]}

Vincken, Jean-Paul ^{[2
]}

Gruppen, Harry ^{[2
]}

Witkamp, Renger ^{[1
]}

Gabriele, Bartolo ^{[3
]}

机构：

[1] Wageningen Univ, Div Human Nutr, NL-6700 EV Wageningen, Netherlands

[2] Wageningen Univ, Food Chem Lab, NL-6700 EV Wageningen, Netherlands

[3] Univ Calabria, Dipartimento Sci Farmaceut, I-87036 Cosenza, Italy

来源：

LETTERS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 06期

关键词：

Acylation; enzymatic catalysis; lipase; unsaturated N-acylethanolamines; unsaturated fatty acids; ENZYMATIC-SYNTHESIS; AMIDE SURFACTANTS; CARBOXYLIC-ACIDS; IONIC LIQUIDS; SOLVENT; ANANDAMIDE; ENDOCANNABINOIDS; AMIDATION; PRESSURE; AMINES;

D O I：

10.2174/157017809789124885

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective synthesis of unsaturated N-acylethanolamines 1b-6b by lipase-catalyzed direct condensation between unsaturated fatty acids 1a-6a and ethanolamine is reported. Reactions were carried out in hexane at 40 degrees C, in the presence of Candida antarctica Lipase B as the catalyst, to give the corresponding amides 1b-6b with yields ranging from 80 to 88%.

引用

页码：444 / 447

页数：4

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