Polyionic complex of single-walled carbon nanotubes and PEG-grafted-hyperbranched polyethyleneimine (PEG-PEI-SWNT) for an improved doxorubicin loading and delivery: development and in vitro characterization

被引：24

作者：

Farvadi, Fakhrossadat ^{[1
]}

Tamaddon, AliMohammad ^{[2
,3
]}

Sobhani, Zahra ^{[4
]}

Abolmaali, Samira Sadat ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Dept Pharmaceut Nanotechnol, Shiraz, Iran

[2] Shiraz Univ Med Sci, Ctr Nanotechnol Drug Delivery, Shiraz, Iran

[3] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Nanotechnol, Shiraz, Iran

[4] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut, Shiraz, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Cancer therapy; carbon nanotube; doxorubicin; PEG-grafted polyethyleneimine; polyionic complexation; DRUG-DELIVERY; TARGETED DELIVERY; GENE DELIVERY; CANCER-CELLS; DNA; TRANSFECTION; RESISTANT; COPOLYMER; GLYCOL);

D O I：

10.1080/21691401.2016.1181642

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeutic agents (e.g. doxorubicin) in order to decrease general toxicities of doxorubicin (DOX) and to promote the efficacy, we aimed to develop a novel approach to stabilize SWNTs through consequent steps of oxidation and PEG-g-PEI polyionic complexation (PEG-PEI-SWNT). The DOX loading capacity of modified SWNTs was about 900%. Moreover, it showed an enhanced dispersibility in physiologic-stimulated medium. DOX release was prolonged, independent of dilution, and exhibited an acidic pH-stimulated release. Therefore, PEG-PEI-SWNT could be used for cancer chemotherapy in vivo.

引用

页码：855 / 863

页数：9

共 33 条

[1] Chemically crosslinked nanogels of PEGylated poly ethyleneimine (L-histidine substituted) synthesized via metal ion coordinated self-assembly for delivery of methotrexate: Cytocompatibility, cellular delivery and antitumor activity in resistant cells [J].

Abolmaali, Samira Sadat ;

Tamaddon, Ali Mohammad ;

Mohammadi, Samaneh ;

Amoozgar, Zohreh ;

Dinarvand, Rasoul .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 62 :897-907

[2] Sequential optimization of methotrexate encapsulation in micellar nano-networks of polyethyleneimine ionomer containing redox-sensitive cross-links [J].

Abolmaali, Samira Sadat ;

Tamaddon, Ali ;

Yousefi, Gholamhossein ;

Javidnia, Katayoun ;

Dinarvand, Rasoul .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :2833-2848

[3] Nano-hydrogels of methoxy polyethylene glycol-grafted branched polyethyleneimine via biodegradable cross-linking of Zn2+-ionomer micelle template [J].

Abolmaali, Samira Sadat ;

Tamaddon, Ali Mohammad ;

Dinarvand, Rasoul .

JOURNAL OF NANOPARTICLE RESEARCH, 2013, 15 (12)

[4] Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics [J].

Ali-Boucetta, Hanene ;

Al-Jamal, Khuloud T. ;

McCarthy, David ;

Prato, Maurizio ;

Bianco, Alberto ;

Kostarelos, Kostas .

CHEMICAL COMMUNICATIONS, 2008, (04) :459-461

[5] Synthesis of water-soluble PEGylated single-walled carbon nanotubes [J].

Chattopadhyay, Jayanta ;

de Jesus Cortez, Felipe ;

Chakraborty, Soma ;

Slater, Nigel K. H. ;

Billups, W. E. .

CHEMISTRY OF MATERIALS, 2006, 18 (25) :5864-5868

[6]

Farvadi F, 2014, RES PHARM SCI, V9, P1

[7] Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field [J].

Gannon, Christopher J. ;

Cherukuri, Paul ;

Yakobson, Boris I. ;

Cognet, Laurent ;

Kanzius, John S. ;

Kittrell, Carter ;

Weisman, R. Bruce ;

Pasquali, Matteo ;

Schmidt, Howard K. ;

Smalley, Richard E. ;

Curley, Steven A. .

CANCER, 2007, 110 (12) :2654-2665

[8] Determination of the acidic sites of purified single-walled carbon nanotubes by acid-base titration [J].

Hu, H ;

Bhowmik, P ;

Zhao, B ;

Hamon, MA ;

Itkis, ME ;

Haddon, RC .

CHEMICAL PHYSICS LETTERS, 2001, 345 (1-2) :25-28

[9] Dispersion rheology of carbon nanotubes in a polymer matrix [J].

Huang, YY ;

Ahir, SV ;

Terentjev, EM .

PHYSICAL REVIEW B, 2006, 73 (12)

[10] Carbon nanotube based biomedical agents for heating, temperature sensoring and drug delivery [J].

Klingeler, Ruediger ;

Hampel, Silke ;

Buechner, Bernd .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2008, 24 (06) :496-505

← 1 2 3 4 →