QT interval prolongation and torsade de pointes associated with indapamide

被引：17

作者：

Letsas, Konstantinos P. ^{[1
]}

Alexanian, Ioannis P. ^{[1
]}

Pappas, Loukas K. ^{[1
]}

Kounas, Stavros P. ^{[1
]}

Efremidis, Michalis ^{[1
]}

Sideris, Antonios ^{[1
]}

Kardaras, Fotis ^{[1
]}

机构：

[1] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Athens 10676, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2006年 / 112卷 / 03期

关键词：

indapamide; long QT; torsade de pointes; DIURETIC AGENT INDAPAMIDE; I-KS; COMPONENT; MYOCYTES; BLOCK;

D O I：

10.1016/j.ijcard.2005.07.055

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：373 / 374

页数：2

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