On the compressibility and poroelasticity of human and murine skin

被引：53

作者：

Wahlsten, Adam ^{[1
]}

Pensalfini, Marco ^{[1
]}

Stracuzzi, Alberto ^{[1
]}

Restivo, Gaetana ^{[2
]}

Hopf, Raoul ^{[1
,3
]}

Mazza, Edoardo ^{[1
,3
]}

机构：

[1] Swiss Fed Inst Technol, Inst Mech Syst, Dept Mech & Proc Engn, CH-8092 Zurich, Switzerland

[2] Univ Hosp Zurich, Dept Dermatol, CH-8091 Zurich, Switzerland

[3] Empa, Swiss Fed Labs Mat Sci & Technol, CH-8600 Dubendorf, Switzerland

来源：

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY | 2019年 / 18卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

Skin biomechanics; Mechanical characterization; Compressibility; Porous media; Osmotic pressure; FIELD BULGE TEST; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; INTERVERTEBRAL DISC; VOLUME COMPRESSIBILITY; VISCOELASTIC BEHAVIOR; ARTICULAR-CARTILAGE; UNIAXIAL TENSION; FLUID-FLOW; DEFORMATION;

D O I：

10.1007/s10237-019-01129-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A total of 37 human and 33 murine skin samples were subjected to uniaxial monotonic, cyclic, and relaxation experiments. Detailed analysis of the three-dimensional kinematic response showed that skin volume is significantly reduced as a consequence of a tensile elongation. This behavior is most pronounced in monotonic but persists in cyclic tests. The dehydration associated with volume loss depends on the osmolarity of the environment, so that tension relaxation changes as a consequence of modifying the ionic strength of the environmental bath. Similar to ex vivo observations, complementary in vivo stretching experiments on human volar forearms showed strong in-plane lateral contraction. A biphasic homogenized model is proposed which allows representing all relevant features of the observed mechanical response.

引用

页码：1079 / 1093

页数：15

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