Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa

被引：56

作者：

Sugahara, Masako ^{[1
]}

Miyata, Manabu ^{[1
]}

Ishihara, Kenji ^{[1
]}

Gotoh, Norimoto ^{[1
]}

Morooka, Satoshi ^{[1
]}

Ogino, Ken ^{[1
]}

Hasegawa, Tomoko ^{[1
]}

Hirashima, Takako ^{[1
]}

Yoshikawa, Munemitsu ^{[1
]}

Hata, Masayuki ^{[1
]}

Muraoka, Yuki ^{[1
]}

Ooto, Sotaro ^{[1
]}

Yamashiro, Kenji ^{[1
]}

Yoshimura, Nagahisa ^{[1
]}

机构：

[1] Kyoto Univ, Dept Ophthalmol & Visual Sci, Grad Sch Med, Sakyo Ku, Shogoin Kawahara Cho 54, Kyoto, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

THICKNESS; ASSOCIATION; FEATURES; DENSITY;

D O I：

10.1038/srep46396

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ophthalmologists sometimes face difficulties in identifying the origin of visual acuity (VA) loss in a retinitis pigmentosa (RP) patient, particularly before cataract surgery: cataract or the retinal disease state. Therefore, it is important to identify the significant factors correlating with VA. Nowadays, retinal blood flow in superficial and deep layers can be estimated non-invasively using optical coherence tomography angiography (OCTA). We estimated blood flow per retinal layer by using OCTA; investigated the correlation between VA and other parameters including blood flow and retinal thickness; and identified the most associated factor with VA in patients with RP. OCTA images in 68 of consecutive 110 Japanese RP patients were analysable (analysable RP group). Thirty-two age-and axial length-matched healthy eyes (control group) were studied. In the analysable RP group, the parafoveal flow density in superficial and deep layers was 47.0 +/- 4.9% and 52.4 +/- 5.5%, respectively, which was significantly lower than that in controls. Using multivariate analysis, we found that the parafoveal flow density in the deep layer and superficial foveal avascular area were the factors associated with VA. Noninvasive estimation of retinal blood flow per retinal layer using OCTA is useful for predicting VA in RP patients.

引用

页数：10

共 27 条

[1] Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa [J].