Temozolomide Treatment for Pediatric Refractory Anaplastic Ependymoma with Low MGMT Protein Expression

被引：6

作者：

Komori, Kazutoshi ^{[1
,2
]}

Yanagisawa, Ryu ^{[1
,2
]}

Miyairi, Yosuke ^{[3
]}

Sakashita, Kazuo ^{[1
,2
]}

Shiohara, Masaaki ^{[4
]}

Fujihara, Ikuko ^{[1
]}

Morita, Daisuke ^{[2
]}

Nakamura, Tomohiko ^{[1
,5
]}

Ogiso, Yoshifumi ^{[6
]}

Sano, Kenji ^{[7
]}

Shirahata, Mitsuaki ^{[8
]}

Fukuoka, Kohei ^{[9
]}

Ichimura, Koichi ^{[9
]}

Shigeta, Hiroaki ^{[3
]}

机构：

[1] Nagano Childrens Hosp, Dept Hematol Oncol, Azumino, Japan

[2] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 390, Japan

[3] Nagano Childrens Hosp, Dept Neurosurg, Azumino, Japan

[4] Matsumoto Dent Univ, Sch Dent, Dept Pediat, Matsumoto, Nagano, Japan

[5] Nagano Childrens Hosp, Life Sci Res Ctr, Azumino, Japan

[6] Nagano Childrens Hosp, Dept Clin Pathol, Azumino, Japan

[7] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan

[8] Saitama Med Univ, Int Med Ctr, Dept Neurooncol Neurosurg, Hidaka, Japan

[9] Natl Canc Ctr, Res Inst, Div Brain Tumor Translat Res, Tokyo 104, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2016年 / 63卷 / 01期

基金：

日本学术振兴会;

关键词：

ependymoma; MGMT; O-6-methylguanine-DNA methyltransferase; temozolomide; RECURRENT EPENDYMOMA; CHEMOTHERAPY; CHILDREN; RADIOTHERAPY; RESECTION; SURVIVAL; BENEFIT;

D O I：

10.1002/pbc.25696

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The benefit of postoperative chemotherapy for anaplastic ependymoma remains unknown. We report two pediatric patients with refractory anaplastic ependymoma treated with temozolomide (TMZ). We did not detect O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in tumor samples; however, MGMT protein expression was low. With TMZ treatment, one patient had a 7-month complete remission; the other, stable disease for 15 months. Three other patients did not respond to TMZ; two had high and one low MGMT expression, and two showed no MGMT promoter methylation. These findings suggest that TMZ may be effective for pediatric refractory anaplastic ependymoma with low MGMT protein expression. Pediatr Blood Cancer (c) 2015 Wiley Periodicals, Inc.

引用

页码：152 / 155

页数：4

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