The relationship between TRAF6 and tumors

被引：48
作者：
Li, Jiaoduan [1 ,2 ,3 ,4 ,5 ]
Liu, Nian [1 ,2 ,3 ,4 ,5 ]
Tang, Ling [1 ,2 ,3 ,4 ,5 ]
Yan, Bei [1 ,2 ,3 ,4 ,5 ]
Chen, Xiang [1 ,2 ,3 ,4 ,5 ]
Zhang, Jianglin [1 ,2 ,3 ,4 ,5 ]
Peng, Cong [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China
[2] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China
[3] Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China
[4] Xiangya Hosp, Hunan Engn Res Ctr Skin Hlth & Dis, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Clin Res Ctr Canc Immunotherapy, Changsha, Hunan, Peoples R China
来源：
CANCER CELL INTERNATIONAL | 2020年 / 20卷 / 01期
基金：
中国国家自然科学基金; 国家自然科学基金国际合作与交流项目;
关键词：
TRAF6; Tumorigenesis; E3 ubiquitin ligase; AP-1; NF-kappa B; NF-KAPPA-B; TARGETING TRAF6; DEUBIQUITINATING ENZYME; PANCREATIC-CANCER; INNATE IMMUNITY; DOWN-REGULATION; POOR-PROGNOSIS; UBIQUITIN; PROMOTES; METASTASIS;
D O I：
10.1186/s12935-020-01517-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development. With the in-depth study of the relationship between TRAF6 and different types of tumors, TRAF6 has oncogenic characteristics involved in tumorigenesis, tumor development, invasion, and metastasis through various signaling pathways, therefore, targeting TRAF6 has provided a novel strategy for tumor treatment. This review summarizes and analyzes the role of TRAF6 in tumorigenesis and tumor development in combination with the current research on TRAF6 and tumors.
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页数：12
相关论文
共 118 条
[1]   Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1) [J].
Arcipowski, Kelly M. ;
Stunz, Laura L. ;
Graham, John P. ;
Kraus, Zachary J. ;
Vanden Bush, Tony J. ;
Bishop, Gail A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (12) :9948-9955
[2]  
Ardecky R., 2010, Probe Reports from the NIH Molecular Libraries Program
[3]   Epithelial mesenchymal interactions in cancer and development [J].
Arias, AM .
CELL, 2001, 105 (04) :425-431
[4]   TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer [J].
Aripaka, Karthik ;
Gudey, Shyam Kumar ;
Zang, Guangxiang ;
Schmidt, Alexej ;
Ahrling, Samaneh Shabani ;
Osterman, Lennart ;
Bergh, Anders ;
von Hofsten, Jonas ;
Landstrom, Marene .
EBIOMEDICINE, 2019, 45 :192-207
[5]   Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis [J].
Bao, Xin ;
Shi, Jianbo ;
Xie, Furong ;
Liu, Zengying ;
Yu, Jingshuang ;
Chen, Wantao ;
Zhang, Zhiyuan ;
Xu, Qin .
CANCER RESEARCH, 2018, 78 (09) :2262-2276
[6]   TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation [J].
Bishop, Gail A. ;
Stunz, Laura L. ;
Hostager, Bruce S. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[7]   Tumor necrosis factor receptor-associated factors (TRAFs) [J].
Bradley, JR ;
Pober, JS .
ONCOGENE, 2001, 20 (44) :6482-6491
[8]   Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity [J].
Brenke, Jara K. ;
Popowicz, Grzegorz M. ;
Schorpp, Kenji ;
Rothenaigner, Ina ;
Roesner, Manfred ;
Meininger, Isabel ;
Kalinski, Cedric ;
Ringelstetter, Larissa ;
R'kyek, Omar ;
Juerjens, Gerrit ;
Vincendeau, Michelle ;
Plettenburg, Oliver ;
Sattler, Michael ;
Krappmann, Daniel ;
Hadian, Kamyar .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (34) :13191-13203
[9]   TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor [J].
Bruneau, Sarah ;
Datta, Dipak ;
Flaxenburg, Jesse A. ;
Pal, Sournitro ;
Briscoe, David M. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 419 (01) :66-71
[10]   The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains [J].
Budhidarmo, Rhesa ;
Zhu, Jingyi ;
Middleton, Adam J. ;
Day, Catherine L. .
FEBS LETTERS, 2018, 592 (08) :1434-1444
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