The relationship between TRAF6 and tumors

被引：40

作者：

Li, Jiaoduan ^{[1
,2
,3
,4
,5
]}

Liu, Nian ^{[1
,2
,3
,4
,5
]}

Tang, Ling ^{[1
,2
,3
,4
,5
]}

Yan, Bei ^{[1
,2
,3
,4
,5
]}

Chen, Xiang ^{[1
,2
,3
,4
,5
]}

Zhang, Jianglin ^{[1
,2
,3
,4
,5
]}

Peng, Cong ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China

[2] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China

[3] Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China

[4] Xiangya Hosp, Hunan Engn Res Ctr Skin Hlth & Dis, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Clin Res Ctr Canc Immunotherapy, Changsha, Hunan, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2020年 / 20卷 / 01期

基金：

国家自然科学基金国际合作与交流项目; 中国国家自然科学基金;

关键词：

TRAF6; Tumorigenesis; E3 ubiquitin ligase; AP-1; NF-kappa B; NF-KAPPA-B; TARGETING TRAF6; DEUBIQUITINATING ENZYME; PANCREATIC-CANCER; INNATE IMMUNITY; DOWN-REGULATION; POOR-PROGNOSIS; UBIQUITIN; PROMOTES; METASTASIS;

D O I：

10.1186/s12935-020-01517-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development. With the in-depth study of the relationship between TRAF6 and different types of tumors, TRAF6 has oncogenic characteristics involved in tumorigenesis, tumor development, invasion, and metastasis through various signaling pathways, therefore, targeting TRAF6 has provided a novel strategy for tumor treatment. This review summarizes and analyzes the role of TRAF6 in tumorigenesis and tumor development in combination with the current research on TRAF6 and tumors.

引用

页数：12

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