Total synthesis of (+)-kopsihainanine A

被引：32

作者：

Mizutani, Masaya ^{[1
]}

Yasuda, Shigeo ^{[1
]}

Mukai, Chisato ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 43期

关键词：

CATALYZED DECARBOXYLATIVE ALLYLATION; DIHYDROXYLATION; CARBAZOLONES; ALKALOIDS; SYSTEM;

D O I：

10.1039/c4cc01843e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total synthesis of (+)-kopsihainanine A was accomplished on the basis of (i) Stoltz's enantioselective decarboxylative asymmetric allylation and (ii) the proposed biogenetic pathway from the related alkaloid, kopsihainanine B. In addition, HPLC analysis of the synthetic (+)-kopsihainanine A confirmed its ee to be 99% with [alpha](D)(30) = 25.35.

引用

页码：5782 / 5785

页数：4

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