Bortezomib-thalidomide-dexamethasone (VTD) is superior to bortezomib-cyclophosphamide-dexamethasone (VCD) as induction therapy prior to autologous stem cell transplantation in multiple myeloma

被引：50

作者：

Cavo, M. ^{[1
]}

Pantani, L. ^{[1
]}

Pezzi, A. ^{[1
]}

Petrucci, M. T. ^{[2
]}

Patriarca, F. ^{[3
]}

Di Raimondo, F. ^{[4
]}

Marzocchi, G. ^{[1
]}

Galli, M. ^{[5
]}

Montefusco, V. ^{[6
]}

Zamagni, E. ^{[1
]}

Gamberi, B. ^{[7
]}

Tacchetti, P. ^{[1
]}

Brioli, A. ^{[1
]}

Palumbo, A. ^{[8
]}

Sonneveld, P. ^{[9
]}

机构：

[1] Univ Bologna, Sch Med, Seragnoli Inst Hematol, Bologna, Italy

[2] Univ Roma La Sapienza, Azienda Policlin Umberto 1, I-00185 Rome, Italy

[3] Hematol & Bone Marrow Transplant Unit, Udine, Italy

[4] Univ Catania, Dept Clin & Mol Biomed, Catania, Italy

[5] Papa Giovanni XXIII Hosp, Hematol, Bergamo, Italy

[6] Fdn IRCCS Ist Nazl Tumori, Hematol Bone Marrow Transplantat, Milan, Italy

[7] Arcispedale S Maria Nuova, Hematol, Reggio Emilia, Italy

[8] Univ Turin, AOU S Giovanni Battista Torino, Turin, Italy

[9] Erasmus MC, Dept Hematol, Rotterdam, Netherlands

来源：

LEUKEMIA | 2015年 / 29卷 / 12期

关键词：

RANDOMIZED PHASE-3; PLUS DEXAMETHASONE; TRIAL; CYBORD;

D O I：

10.1038/leu.2015.274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：2429 / 2431

页数：4

共 15 条

[1] CyBorD induction therapy in clinical practice [J].

Areethamsirikul, N. ;

Masih-Khan, E. ;

Chu, C-M ;

Jimenez-Zepeda, V. ;

Reece, D. E. ;

Trudel, S. ;

Kukreti, V. ;

Tiedemann, R. ;

Chen, C. .

BONE MARROW TRANSPLANTATION, 2015, 50 (03) :375-379

[2] The impact of intra-clonal heterogeneity on the treatment of multiple myeloma [J].

Brioli, Annamaria ;

Melchor, Lorenzo ;

Cavo, Michele ;

Morgan, Gareth J. .

BRITISH JOURNAL OF HAEMATOLOGY, 2014, 165 (04) :441-454

[3] International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation [J].

Cavo, Michele ;

Rajkumar, S. Vincent ;

Palumbo, Antonio ;

Moreau, Philippe ;

Orlowski, Robert ;

Blade, Joan ;

Sezer, Orhan ;

Ludwig, Heinz ;

Dimopoulos, Meletios A. ;

Attal, Michel ;

Sonneveld, Pieter ;

Boccadoro, Mario ;

Anderson, Kenneth C. ;

Richardson, Paul G. ;

Bensinger, William ;

Johnsen, Hans E. ;

Kroeger, Nicolaus ;

Gahrton, Gosta ;

Bergsagel, P. Leif ;

Vesole, David H. ;

Einsele, Hermann ;

Jagannath, Sundar ;

Niesvizky, Ruben ;

Durie, Brian G. M. ;

San Miguel, Jesus ;

Lonial, Sagar .

BLOOD, 2011, 117 (23) :6063-6073

[4] Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study [J].

Cavo, Michele ;

Tacchetti, Paola ;

Patriarca, Francesca ;

Petrucci, Maria Teresa ;

Pantani, Lucia ;

Galli, Monica ;

Di Raimondo, Francesco ;

Crippa, Claudia ;

Zamagni, Elena ;

Palumbo, Antonio ;

Offidani, Massimo ;

Corradini, Paolo ;

Narni, Franco ;

Spadano, Antonio ;

Pescosta, Norbert ;

Deliliers, Giorgio Lambertenghi ;

Ledda, Antonio ;

Cellini, Claudia ;

Caravita, Tommaso ;

Tosi, Patrizia ;

Baccarani, Michele .

LANCET, 2010, 376 (9758) :2075-2085

[5] International uniform response criteria for multiple myeloma [J].

Durie, B. G. M. ;

Harousseau, J-L ;

Miguel, J. S. ;

Blade, J. ;

Barlogie, B. ;

Anderson, K. ;

Gertz, M. ;

Dimopoulos, M. ;

Westin, J. ;

Sonneveld, P. ;

Ludwig, H. ;

Gahrton, G. ;

Beksac, M. ;

Crowley, J. ;

Belch, A. ;

Boccadaro, M. ;

Turesson, I. ;

Joshua, D. ;

Vesole, D. ;

Kyle, R. ;

Alexanian, R. ;

Tricot, G. ;

Attal, M. ;

Merlini, G. ;

Powles, R. ;

Richardson, P. ;

Shimizu, K. ;

Tosi, P. ;

Morgan, G. ;

Rajkumar, S. V. .

LEUKEMIA, 2006, 20 (09) :1467-1473

[6] Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma [J].

Kumar, Shaji ;

Flinn, Ian ;

Richardson, Paul G. ;

Hari, Parameswaran ;

Callander, Natalie ;

Noga, Stephen J. ;

Stewart, A. Keith ;

Turturro, Francesco ;

Rifkin, Robert ;

Wolf, Jeffrey ;

Estevam, Jose ;

Mulligan, George ;

Shi, Hongliang ;

Webb, Iain J. ;

Rajkumar, S. Vincent .

BLOOD, 2012, 119 (19) :4375-4382

[7] Bortezomib-Cyclophosphamide-Dexamethasone (VCD) versus Bortezomib-Thalidomide-Dexamethasone (VTD) -based regimens as induction therapies in newly diagnosed transplant eligible patients with multiple myeloma: a meta-analysis [J].

Leiba, Merav ;

Kedmi, Meirav ;

Duek, Adrian ;

Freidman, Tzachi ;

Weiss, Mia ;

Leiba, Ronit ;

Nagler, Arnon ;

Avigdor, Abraham .

BRITISH JOURNAL OF HAEMATOLOGY, 2014, 166 (05) :702-710

[8] Association of response endpoints with survival outcomes in multiple myeloma [J].

Lonial, S. ;

Anderson, K. C. .

LEUKEMIA, 2014, 28 (02) :258-268

[9] Phase III trial of bortezomib, cyclophosphamide and dexamethasone (VCD) versus bortezomib, doxorubicin and dexamethasone (PAd) in newly diagnosed myeloma [J].

Mai, E. K. ;

Bertsch, U. ;

Duerig, J. ;

Kunz, C. ;

Haenel, M. ;

Blau, I. W. ;

Munder, M. ;

Jauch, A. ;

Schurich, B. ;

Hielscher, T. ;

Merz, M. ;

Huegle-Doerr, B. ;

Seckinger, A. ;

Hose, D. ;

Hillengass, J. ;

Raab, M. S. ;

Neben, K. ;

Lindemann, H-W ;

Zeis, M. ;

Gerecke, C. ;

Schmidt-Wolf, I. G. H. ;

Weisel, K. ;

Scheid, C. ;

Salwender, H. ;

Goldschmidt, H. .

LEUKEMIA, 2015, 29 (08) :1721-1729

[10] Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma [J].

Moreau, Philippe ;

Avet-Loiseau, Herve ;

Facon, Thierry ;

Attal, Michel ;

Tiab, Mourad ;

Hulin, Cyrille ;

Doyen, Chantal ;

Garderet, Laurent ;

Randriamalala, Edouard ;

Araujo, Carla ;

Lepeu, Gerard ;

Marit, Gerald ;

Caillot, Denis ;

Escoffre, Martine ;

Lioure, Bruno ;

Benboubker, Lotfi ;

Pegourie, Brigitte ;

Kolb, Brigitte ;

Stoppa, Anne Marie ;

Fuzibet, Jean-Gabriel ;

Decaux, Olivier ;

Dib, Mamoun ;

Berthou, Christian ;

Chaleteix, Carine ;

Sebban, Catherine ;

Traulle, Catherine ;

Fontan, Jean ;

Wetterwald, Marc ;

Lenain, Pascal ;

Mathiot, Claire ;

Harousseau, Jean-Luc .

BLOOD, 2011, 118 (22) :5752-5758

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