Synthesis of unsaturated carboxylic and amino acids of adamantane series with the use of organophosphorus reagents

被引：1

作者：

Miryan, NI ^{[1
]}

Isaev, SD ^{[1
]}

Yurchenko, AG ^{[1
]}

Gulyaiko, IV ^{[1
]}

Voinovskaya, TY ^{[1
]}

Rassukana, YV ^{[1
]}

Shchirova, NV ^{[1
]}

机构：

[1] Ukrainian Natl Tech Univ, Polytech Inst, UA-01056 Kiev, Ukraine

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 38卷 / 02期

关键词：

Thermolysis; Triethyl; Phosphonic Acid; Adamantyl; Sodium Hydride;

D O I：

10.1023/A:1015501313852

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sodium derivative of diethyl(3-amino-1-ethoxycarbonylpropane)phosphonic acid was obtained by reaction of triethyl phosphonoacetate with ethylene imine in the presence of sodium hydride. The compound obtained was brought into Horner-Emmons reaction with carbonyl derivatives of adamantane series to afford the corresponding unsaturated amino acids. From adamantanecarbonyl chlorides and triphenylphosphonium ethoxycarbonylmethylide new phosphorus acylylides that on thermolysis provide ethyl acetylenecarboxylates containing an adamantyl substituent were prepared.

引用

页码：188 / 190

页数：3