Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy

被引：44
作者：
Zhu, Runqi [1 ,2 ,3 ]
Lang, Tianqun [1 ,2 ,3 ,4 ]
Yan, Wenlu [1 ,2 ,3 ]
Zhu, Xiao [1 ,2 ,3 ]
Huang, Xin [1 ,2 ,3 ]
Yin, Qi [1 ,2 ,3 ,4 ]
Li, Yaping [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
[3] Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
[4] Yantai Key Lab Nanomed & Adv Preparat, Yantai Inst Mat Med, Yantai 264000, Peoples R China
[5] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
来源：
ADVANCED SCIENCE | 2021年 / 8卷 / 10期
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
cancer therapy; carcinogenesis; drug delivery system; gut microbiota; modulation; FUSOBACTERIUM-NUCLEATUM; COLON-CANCER; HELICOBACTER-PYLORI; COLORECTAL-CANCER; HUMAN HEALTH; MOUSE MODEL; BUTYRATE; INFLAMMATION; BACTERIA; HOST;
D O I：
10.1002/advs.202003542
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gut microbiota have close interactions with the host. It can affect cancer progression and the outcomes of cancer therapy, including chemotherapy, immunotherapy, and radiotherapy. Therefore, approaches toward the modulation of gut microbiota will enhance cancer prevention and treatment. Modern drug delivery systems (DDS) are emerging as rational and promising tools for microbiota intervention. These delivery systems have compensated for the obstacles associated with traditional treatments. In this review, the essential roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced. Next, advances in DDS that are aimed at enhancing the efficacy of cancer therapy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities associated with the application of DDS targeting gut microbiota for cancer prevention and treatment are briefly discussed.
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页数：32
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