Immune reconstitution and severity of COVID-19 among hematopoietic cell transplant recipients

被引：6

作者：

Malek, Alexandre E. ^{[1
]}

Adachi, Javier A. ^{[1
]}

Mulanovich, Victor E. ^{[1
]}

Sassine, Joseph ^{[1
]}

Raad, Issam I. ^{[1
]}

McConn, Kelly ^{[1
]}

Seiler, Garret T. ^{[1
]}

Dhal, Udit ^{[1
]}

Khawaja, Fareed ^{[1
]}

Chemaly, Roy F. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, 1515 Holcombe Blvd, Houston, TX 77030 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2021年

关键词：

COVID-19; hematopoietic cell transplantation; outcomes; pre-engraftment; stem cell therapy;

D O I：

10.1111/tid.13606

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 can lead to life-threatening coronavirus disease 2019 (COVID-19) infections in patients with hematologic malignancies, particularly among hematopoietic cell transplant (HCT) recipients. We describe two patients with COVID-19 during the pre-engraftment period after HCT and review previous reports of COVID-19 in HCT recipients. Because of significant mortality from COVID-19, primarily after allogeneic HCT, early, preemptive, and optimal directed therapy may improve outcomes and reduce the mortality rate but still needs to be established in clinical trials.

引用

页数：7

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