Synergistic ameliorative effects of sesame oil and alpha-lipoic acid against subacute diazinon toxicity in rats: hematological, biochemical, and antioxidant studies

被引:63
作者
Abdel-Daim, Mohamed M. [1 ]
Taha, Ramadan [2 ]
Ghazy, Emad W. [3 ]
El-Sayed, Yasser S. [4 ]
机构
[1] Suez Canal Univ, Fac Vet Med, Dept Pharmacol, Ismailia 41522, Egypt
[2] Suez Canal Univ, Fac Vet Med, Dept Clin Pathol, Ismailia 41522, Egypt
[3] Kafrelsheikh Univ, Fac Vet Med, Dept Clin Pathol, Kafr Al Sheikh 33516, Egypt
[4] Damanhour Univ, Fac Vet Med, Dept Vet Forens Med & Toxicol, Damanhour 22511, Egypt
关键词
diazinon; sesame oil; lipoic acid; antioxidant; oxidative stress; OXIDATIVE STRESS; PROTECTIVE ROLE; INDUCED CARDIOTOXICITY; LIPID-PEROXIDATION; CHLORPYRIFOS-ETHYL; VITAMIN-E; DAMAGE; ERYTHROCYTES; INSECTICIDE; PARAMETERS;
D O I
10.1139/cjpp-2015-0131
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid (ALA) against DZN toxicity in male Wistar albino rats. DZN-treated animals exhibited macrocytic hypochromic anemia and significant increases in serum biochemical parameters related to liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma GT), cholesterol, and triglycerides. They also had elevated levels of markers related to cardiac injury, such as lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), and increased biomarkers of renal injury, urea and creatinine. DZN also increased hepatic, renal, and cardiac lipid peroxidation and decreased antioxidant biomarker levels. SO and (or) ALA supplementation ameliorated the deleterious effects of DZN intoxication. Treatment improved hematology and serum parameters, enhanced endogenous antioxidant status, and reduced lipid peroxidation. Importantly, they exerted synergistic hepatoprotective, nephroprotective, and cardioprotective effects. Our findings demonstrate that SO and (or) ALA supplementation can alleviate the toxic effects of DZN via their potent antioxidant and free radical-scavenging activities.
引用
收藏
页码:81 / 88
页数:8
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