Crystal structure of 1-(adamantan-1-yl)-3(3-chlorophenyl) thiourea, C17H21ClN2S

被引：6
作者：
Al-Omary, Fatmah A. M. [1 ]
Al-Rasheed, Lamees S. [1 ]
Ghabbour, Hazem A. [1 ,2 ]
El-Emam, Ali A. [1 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia
[2] Univ Mansoura, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt
来源：
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2017年 / 232卷 / 01期
关键词：
AMANTADINE HYDROCHLORIDE; POTENT; INHIBITOR; INFLUENZA; EFFICACY; ANALOGS;
D O I：
10.1515/ncrs-2016-0117
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
C17H21ClN2S, orthorhombic, Pca2(1) (no. 29), a = 25.4796(11) angstrom, b = 6.7503(3) angstrom, c = 18.9971(9) angstrom, V = 3267.4(3) angstrom(3), Z = 8, R-gt(F) = 0.045, wR(ref)(F-2) = 0.106, T = 293(2).
引用
收藏
页码：33 / 35
页数：3
相关论文
共 25 条
[1]   Synthesis and SAR of adatanserin:: Novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT1A and 5-HT2 activity as potential anxiolytic and antidepressant agents [J].
Abou-Gharbia, MA ;
Childers, WE ;
Fletcher, H ;
McGaughey, G ;
Patel, U ;
Webb, MB ;
Yardley, J ;
Andree, T ;
Boast, C ;
Kucharik, RJ ;
Marquis, K ;
Morris, H ;
Scerni, R ;
Moyer, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) :5077-5094
[2]   Crystal structure of 1-(adamantan-1-yl)-3-(4-chlorophenyl)thiourea, C17H21ClN2S [J].
Al-Omary, Fatmah A. M. ;
Ghabbour, Hazem A. ;
AlRabiah, Haitham ;
Al-Abdullah, Ebtehal S. ;
El-Emam, Ali A. .
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2016, 231 (03) :707-709
[3]   Crystal structure of 1-(adamantan-1-yl)-3-phenylthiourea, C17H22N2S [J].
Al-Wahaibi, Lamya H. ;
Ghabbour, Hazem A. ;
Mostafa, Gamal A. E. ;
Almutairi, Maha S. ;
El-Emam, Ali A. .
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2016, 231 (02) :593-595
[4]  
[Anonymous], 2009, APEX2 SAINT SADABS
[5]   MEMANTINE IS A POTENT BLOCKER OF N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNELS [J].
BORMANN, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (03) :591-592
[6]   Bromontan, a new doping agent [J].
Burnat, P ;
Payen, A ;
LeBrumantPayen, C ;
Hugon, M ;
Ceppa, F .
LANCET, 1997, 350 (9082) :963-964
[7]   ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE ( AMANTADINE ) [J].
DAVIES, WL ;
HOFFMANN, CE ;
PAULSHOCK, M ;
WOOD, TR ;
HAFF, RF ;
GRUNERT, RR ;
WATTS, JC ;
HERMANN, EC ;
NEUMAYER, EM ;
MCGAHEN, JW .
SCIENCE, 1964, 144 (362) :862-&
[8]   1-(Adamantan-1-yl)-3-(4-fluorophenyl)thiourea [J].
Demirtas, Gunes ;
Dege, Necmi ;
Al-Shehri, Mona M. ;
El-Emam, Ali A. ;
El-Brollosy, Nasser R. ;
Buyukgungor, Orhan .
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 :O1523-+
[9]   Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(I-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones [J].
El-Emam, AA ;
Al-Deeb, OA ;
Al-Omar, M ;
Lehmann, J .
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (19) :5107-5113
[10]   Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2-aminomethyl-4-substituted-1,2,4-triazoline-3-thiones [J].
El-Emam, Ali A. ;
Al-Tamimi, Abdul-Malek S. ;
Al-Omar, Mohamed A. ;
Alrashood, Khalid A. ;
Habib, Elsayed E. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 68 :96-102
123