Interactions of orphanin FQ/nociceptin (OFQ/N) system with immune system factors and hypothalamic-pituitary-adrenal (HPA) axis

被引：9
作者：
Bodera, Pawel [1 ]
Stankiewicz, Wanda [1 ]
Kocik, Janusz [1 ]
机构：
[1] Mil Inst Hyg & Epidemiol, Warsaw, Poland
来源：
PHARMACOLOGICAL REPORTS | 2014年 / 66卷 / 02期
关键词：
Hypothalamic-pituitary-adrenal; Nociceptin/orphanin; CHRONIC-FATIGUE-SYNDROME; NOCICEPTIN-RECEPTOR; ACETYLCHOLINE-RELEASE; STRESS; BRAIN; MODULATION; RAT; HIPPOCAMPUS; MECHANISMS; EXPRESSION;
D O I：
10.1016/j.pharep.2013.12.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Brain-immune system interactions and neurohormonal changes which are induced by psychophysiological factors are growing areas of scientific interest. Central (CNS) and autonomic nervous-endocrine-immune system pathways are connected with a number of behavioral and physiological factors which may be linked to disease susceptibility and progression. Methods: In this paper, influence of orphanin FQ/nociceptin receptor (OFQ/N) on the hypothalamic-pituitary-adrenal (HPA) axis and their influence on the immunological system was reviewed. Conclusions: The neuroendocrine system, in particular the hypothalamic-pituitary-adrenal (HPA) axis, is closely connected with the cytokines. HPA axis activation by cytokines, via the release of glucocorticoids has, in turn, been found to play a critical role in restraining and shaping immune responses. Investigation of the OFQ/N system and G-proteins suggests a role for this receptor as a down-regulator of cytokine, chemoldne and chemokine receptor expression. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. Z o.o. All rights reserved.
引用
收藏
页码：288 / 291
页数：4
相关论文
共 30 条
[1]   Opioids and immune modulation: more questions than answers [J].
Al-Hashimi, M. ;
Scott, S. W. M. ;
Thompson, J. P. ;
Lambert, D. G. .
BRITISH JOURNAL OF ANAESTHESIA, 2013, 111 (01) :80-88
[2]   Infection and vaccination in chronic fatigue syndrome: Myth or reality? [J].
Appel, Shmuel ;
Chapman, Joab ;
Shoenfeld, Yehuda .
AUTOIMMUNITY, 2007, 40 (01) :48-53
[3]   IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins [J].
Beck, RD ;
King, MA ;
Ha, GK ;
Cushman, JD ;
Huang, Z ;
Petitto, JM .
JOURNAL OF NEUROIMMUNOLOGY, 2005, 160 (1-2) :146-153
[4]   Nociceptin inhibition of acetylcholine efflux from different brain areas [J].
Cavallini, S ;
Marino, S ;
Beani, L ;
Bianchi, C ;
Siniscalchi, A .
NEUROREPORT, 2003, 14 (17) :2167-2170
[5]   Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome [J].
Crofford, LJ ;
Young, EA ;
Engleberg, NC ;
Korszun, A ;
Brucksch, CB ;
McClure, LA ;
Brown, MB ;
Demitrack, MA .
BRAIN BEHAVIOR AND IMMUNITY, 2004, 18 (04) :314-325
[6]   From inflammation to sickness and depression: when the immune system subjugates the brain [J].
Dantzer, Robert ;
O'Connor, Jason C. ;
Freund, Gregory G. ;
Johnson, Rodney W. ;
Kelley, Keith W. .
NATURE REVIEWS NEUROSCIENCE, 2008, 9 (01) :46-57
[7]  
Du LN, 1998, ACUPUNCTURE ELECTRO, V23, P1
[8]   Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus [J].
Goeldner, Celia ;
Reiss, David ;
Wichmann, Juergen ;
Meziane, Hamid ;
Kieffer, Brigitte L. ;
Ouagazzal, Abdel-Mouttalib .
JOURNAL OF NEUROSCIENCE, 2008, 28 (09) :2190-2198
[9]   Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War Veterans: Relationships to posttraumatic stress disorder and health symptoms [J].
Golier, Julia A. ;
Schmeidler, James ;
Legge, Juliana ;
Yehuda, Rachel .
BIOLOGICAL PSYCHIATRY, 2007, 62 (10) :1175-1178
[10]   Neural regulation of the stress response: glucocorticoid feedback mechanisms [J].
Herman, J. P. ;
McKlveen, J. M. ;
Solomon, M. B. ;
Carvalho-Netto, E. ;
Myers, B. .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2012, 45 (04) :292-298
123