P-gp Transporter and its Role in Neurodegenerative Diseases

被引：28
作者：
Rapposelli, Simona [1 ]
Digiacomo, Maria [1 ]
Balsamo, Aldo [1 ]
机构：
[1] Univ Pisa, Fac Farm, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 02期
关键词：
P-glycoprotein; Neurodegenerative disorder; Epilepsy; Alzheimer; Parkinson; Hungtington; ALS; BLOOD-BRAIN-BARRIER; AMYOTROPHIC-LATERAL-SCLEROSIS; MEDICALLY INTRACTABLE EPILEPSY; AMYLOID PRECURSOR PROTEIN; INHIBITS 5-LIPOXYGENASE ACTIVATION; CREUTZFELDT-JAKOB-DISEASE; PARKINSONS-DISEASE; ANTIEPILEPTIC DRUGS; IN-VIVO; GLYCOPROTEIN EXPRESSION;
D O I：
10.2174/156802609787521544
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) and Creutzfeldt-Jakob's (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of P-glycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.
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收藏
页码：209 / 217
页数：9
相关论文
共 86 条
[1]   HISTOPATHOLOGICAL CRITERIA FOR PROGRESSIVE DEMENTIA DISORDERS - CLINICAL-PATHOLOGICAL CORRELATION AND CLASSIFICATION BY MULTIVARIATE DATA-ANALYSIS [J].
ALAFUZOFF, I ;
IQBAL, K ;
FRIDEN, H ;
ADOLFSSON, R ;
WINBLAD, B .
ACTA NEUROPATHOLOGICA, 1987, 74 (03) :209-225
[2]   The spatial patterns of prion protein deposits in Creutzfeldt-Jakob disease:: comparison with β-amyloid deposits in Alzheimer's disease [J].
Armstrong, RA ;
Lantos, PL ;
Cairns, NJ .
NEUROSCIENCE LETTERS, 2001, 298 (01) :53-56
[3]   Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death [J].
Arrasate, M ;
Mitra, S ;
Schweitzer, ES ;
Segal, MR ;
Finkbeiner, S .
NATURE, 2004, 431 (7010) :805-810
[4]   DISTRIBUTION OF ALZHEIMER-TYPE PATHOLOGICAL-CHANGES IN NONDEMENTED ELDERLY INDIVIDUALS MATCHES THE PATTERN IN ALZHEIMERS-DISEASE [J].
ARRIAGADA, PV ;
MARZLOFF, K ;
HYMAN, BT .
NEUROLOGY, 1992, 42 (09) :1681-1688
[5]   The novel β-secretase inhibitor KMI-429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild-type mice [J].
Asai, M ;
Hattori, C ;
Iwata, N ;
Saido, TC ;
Sasagawa, N ;
Szabó, B ;
Hashimoto, Y ;
Maruyama, K ;
Tanuma, S ;
Kiso, Y ;
Ishiura, S .
JOURNAL OF NEUROCHEMISTRY, 2006, 96 (02) :533-540
[6]  
Bain LJ, 1996, TOXICOL APPL PHARM, V141, P288, DOI 10.1016/S0041-008X(96)80035-4
[7]   Differences in the transport of the antiepileptic drugs phenytoin, levetiracetarn and carbamazepine by human and mouse P-glycoprotein [J].
Baltes, Steffen ;
Gastens, Alexandra M. ;
Fedrowitz, Maren ;
Potschka, Heidrun ;
Kaever, Volkhard ;
Loescher, Wolfgang .
NEUROPHARMACOLOGY, 2007, 52 (02) :333-346
[8]   Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA [J].
Bartels, A. L. ;
Willemsen, A. T. M. ;
Kortekaas, R. ;
de Jong, B. M. ;
de Vries, R. ;
de Klerk, O. ;
van Oostrom, J. C. H. ;
Portman, A. ;
Leenders, K. L. .
JOURNAL OF NEURAL TRANSMISSION, 2008, 115 (07) :1001-1009
[9]   Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration [J].
Bartels, Anna L. ;
Kortekaas, Rudie ;
Bart, Joost ;
Willemsen, Antoon T. M. ;
de Klerk, Onno L. ;
de Vries, Jeroen J. ;
van Oostrom, Joost C. H. ;
Leenders, Klaus L. .
NEUROBIOLOGY OF AGING, 2009, 30 (11) :1818-1824
[10]   Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling [J].
Bauer, Bjoern ;
Hartz, Anika M. S. ;
Pekcec, Anton ;
Toellner, Kathrin ;
Miller, David S. ;
Potschka, Heidrun .
MOLECULAR PHARMACOLOGY, 2008, 73 (05) :1444-1453
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