pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy

被引：42
|
作者：
Xing, Lei [1 ,2 ,3 ]
Lyu, Jin-Yuan [1 ]
Yang, Yue [4 ]
Cui, Peng-Fei [1 ]
Gu, Liu-Qing [1 ]
Qiao, Jian-Bin [1 ]
He, Yu-Jing [1 ]
Zhang, Tian-Qi [1 ]
Sun, Minjie [1 ]
Lu, Jin-Jian [5 ]
Xu, Xiaojun [1 ]
Liu, Yu [4 ]
Jiang, Hu-Lin [1 ,2 ,3 ]
机构：
[1] China Pharmaceut Univ, State Key Lab Nat Med, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Druggabil Biopharmaceut, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
[4] China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, Nanjing 210009, Jiangsu, Peoples R China
[5] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 62期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
DRUG-DELIVERY; APOPTOSIS; CASPASE-3; POLYMERS; CELLS;
D O I：
10.1039/c7cc04058j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have developed mitochondria-targeted self-assembled nano-particles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.
引用
收藏
页码：8790 / 8793
页数：4
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