Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease

被引:39
作者
Grundmann-Kollmann, M
Martin, H
Ludwig, R
Klein, S
Boehncke, WH
Hoelzer, D
Kaufmann, R
Podda, M
机构
[1] Goethe Univ Frankfurt, Dept Dermatol, D-60590 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Dept Haematol, D-6000 Frankfurt, Germany
关键词
D O I
10.1097/00007890-200212150-00023
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Graft versus host disease (GVHD) is an important problem following allogenic bone m arrow transplantation (BMT). The beneficial effects of photochemotherapy with psoralens plus UVA irradiation (PUVA) have been described repeatedly; however, PUVA is limited by a wide range of unwanted effects. A novel improved form of UV-B phototherapy, narrowband UV-B, has been proven to be very effective in T-cell mediated dermatoses. Therefore, we investigated the effect of narrowband UV-B phototherapy (5 times per week) in 10 patients with cutaneous GVHD (grade 2-3) resistant to standard immunosuppressive drugs. It was tolerated well by all patients, and no side effects were observed. Skin lesions showed complete clearance in 7 out of 10 patients within 3 to 5 weeks. 3 patients showed, significant improvement of GVHD. We suggest that narrowband UV-B phototherapy is a nonaggressive treatment that may benefit patients with cutaneous GVHD who already take high doses of immunosuppressive drugs.
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页码:1631 / 1634
页数:4
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