Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway

被引：40
作者：
Ma, Jie-Qiong [1 ]
Zhang, Yu-Jia [2 ]
Tian, Zhi-Kai [2 ]
Liu, Chan-Min [2 ]
机构：
[1] Sichuan Univ Sci & Engn, Sch Chem Engn, 180 Huixing Rd, Zigong City 643000, Sichuan, Peoples R China
[2] Jiangsu Normal Univ, Sch Life Sci, Tongshan New Area, 101 Shanghai Rd, Xuzhou 221116, Jiangsu, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 90卷
基金：
中国国家自然科学基金;
关键词：
Bixin; Renal inflammation; Fibrosis; Oxidative stress; Nrf2; PPAR-gamma; CCL4-INDUCED HEPATIC-FIBROSIS; PPAR-GAMMA EXPRESSION; LIVER FIBROSIS; LUNG INJURY; PROTECTS; RATS; MICE; NEPHROTOXICITY; INHIBITION; ACTIVATION;
D O I：
10.1016/j.intimp.2020.107117
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bixin, an natural carotenoid extracted from the seeds of the Bixa orellana has been shown to possess numerous important pharmacological activities. The present study was aimed to investigate the mechanisms of Bixin on carbon tetrachloride (CCl4)-induced kidney inflammation, fibrosis and oxidative stress in mice. Our results showed that Bixin improved renal damage by decreasing the serum levels of creatinine, urea, uric acid and alleviating kidney fibrosis. Bixin ameliorated CCl4-induced inflammation in kidneys by reducing the levels of TNF-alpha and IL-1 beta. Bixin suppressed oxidative stress by decreasing the MDA level and increasing the activation of SOD, CAT and GPx. Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice. Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappa B, TGF-beta and Smad3. Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and antifibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways.
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页数：8
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