Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease

被引：30

作者：

Tatari-Calderone, Zohreh ^{[1
,2
]}

Gordish-Dressman, Heather ^{[3
,4
]}

Fasano, Ross ^{[2
,5
,6
]}

Riggs, Michael ^{[7
]}

Fortier, Catherine ^{[8
]}

Campbell, Andrew D. ^{[9
]}

Charron, Dominique ^{[8
]}

Gordeuk, Victor R. ^{[10
]}

Luban, Naomi L. C. ^{[2
,5
,6
]}

Vukmanovic, Stanislav ^{[1
,2
]}

Tamouza, Ryad ^{[8
]}

机构：

[1] Childrens Natl Hlth Syst, Sheikh Zayed Inst Pediat Surg Innovat, 111 Michigan Ave,NW, Washington, DC USA

[2] George Washington Univ, Sch Med & Hlth Sci, Dept Pediat, Washington, DC 20052 USA

[3] George Washington Univ, Sch Med & Hlth Sci, Integrat Syst Biol, Washington, DC 20052 USA

[4] Childrens Natl Hlth Syst, Med Genet Res Ctr, Washington, DC USA

[5] Childrens Natl Hlth Syst, Div Hematol & Oncol, Washington, DC USA

[6] Childrens Natl Med Ctr, Div Lab Med, Washington, DC 20010 USA

[7] Cato Res, Dept Biostat, Durham, NC USA

[8] Hop St Louis, INSERM, UMRS 1160, Lab Jean Dausset & LabEx Transplantex,UMR 1160, Paris, France

[9] Univ Michigan Hlth Syst, Div Pediat Hematol Oncol, Ann Arbor, MI USA

[10] Univ Illinois, Ctr Comprehens Sickle Cell, Sect Hematol Oncol, Chicago, IL USA

来源：

HUMAN IMMUNOLOGY | 2016年 / 77卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HLA-DQB1; HLA-DRB1; Alloimmunization; Red Blood Cell transfusion; Sickle cell disease; HEMOLYTIC TRANSFUSION REACTION; ASSOCIATION; RESPONSES; RISK; ACTIVATION; ARTHRITIS; CHILDREN; ANTIGENS; STROKE; GENES;

D O I：

10.1016/j.humimm.2015.10.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Alloimmunization or the development of alloantibodies to Red Blood Cell (RBC) antigens is considered one of the major complications after RBC transfusions in patients with sickle cell disease (SCD) and can lead to both acute and delayed hemolytic reactions. It has been suggested that polymorphisms in HLA genes, may play a role in alloimmunization. We conducted a retrospective study analyzing the influence of HLA-DRB1 and DQB1 genetic diversity on RBC-alloimmunization. Study design: Two-hundred four multi-transfused SCD patients with and without RBC-alloimmunization were typed at low/medium resolution by PCR-SSO, using IMGT-HLA Database. HLA-DRB1 and DQB1 allele frequencies were analyzed using logistic regression models, and global p-value was calculated using multiple logistic regression. Results: While only trends towards associations between HLA-DR diversity and alloimmunization were observed, analysis of HLA-DQ showed that HLA-DQ2 (p = 0.02), -DQ3 (p = 0.02) and -DQ5 (p = 0.01) alleles were significantly higher in non-alloimmunized patients, likely behaving as protective alleles. In addition, multiple logistic regression analysis showed both HLA-DQ2/6 (p = 0.01) and HLA-DQ5/5 (p = 0.03) combinations constitute additional predictor of protective status. Conclusion: Our data suggest that particular HLA-DQ alleles influence the clinical course of RBC transfusion in patients with SCD, which could pave the way towards predictive strategies. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：35 / 40

页数：6

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