An efficient cascade synthesis of various 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-halo-amides catalyzed by CuI

被引：55

作者：

Chen, Dingben ^{[1
,2
]}

Shen, Guodong ^{[1
]}

Bao, Weiliang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China

[2] Taizhou Univ, Coll Pharmaceut & Chem Engn, Linhai 317000, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 19期

关键词：

ONE-POT SYNTHESIS; COUPLING REACTIONS; ARYL BROMIDES; C-N; COPPER; DERIVATIVES; ACIDS; IODOPHENOLS; SUBSTITUENT; AMINATION;

D O I：

10.1039/b906210f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient one-pot cascade synthesis of 2H-1,4-benzoxazin-3-(4H)-ones has been developed through copper-catalyzed coupling of o-halophenols and 2-halo-amides. Various 2H-1,4-benzoxazin-3-(4H)-ones with diversity at three substituents on their scaffold have been synthesized conveniently in good to excellent yields.

引用

页码：4067 / 4073

页数：7

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