The Youden Index in the Generalized Receiver Operating Characteristic Curve Context

被引：110

作者：

Martinez-Camblor, Pablo ^{[1
]}

Carlos Pardo-Fernandez, Juan ^{[2
,3
]}

机构：

[1] Dartmouth Coll, Dartmouth Inst Hlth Policy & Clin Practice, 7 Lebanon St,Suite 309,Hinman Box 7251, Hanover, NH 03755 USA

[2] Univ Vigo, Dept Stat & OR, Vigo, Spain

[3] Univ Vigo, Biomed Res Ctr, Vigo, Spain

来源：

INTERNATIONAL JOURNAL OF BIOSTATISTICS | 2019年 / 15卷 / 01期

关键词：

(Bio)markers; cutoff point; generalized receiver-operating characteristic (gROC) curve; receiver-operating characteristic (ROC) curve; Youden index; CONFIDENCE-INTERVALS; POINT; ACCURACY;

D O I：

10.1515/ijb-2018-0060

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker to distinguish between two populations. This paper presents the concept of Youden index in the context of the generalized ROC (gROC) curve for non-monotone relationships. The interval estimation of the Youden index and the associated cutoff points in a parametric (binormal) and a non-parametric setting is considered. Monte Carlo simulations and a real-world application illustrate the proposed methodology.

引用

页数：20

共 28 条

[1]

BORODIN A. N., 2002, PROBABILITY ITS APPL, DOI [DOI 10.1007/978-3-0348-8163-0, 10.1007/978-3-0348-8163-0]

[2] Receiver operating characteristic studies and measurement errors [J].