Copper-catalyzed direct alkylation of heteroarenes

被引：81

作者：

Theunissen, Cedric ^{[1
]}

Wang, Jianjun ^{[1
]}

Evano, Gwilherm ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Lab Chim Organ, Serv Chim & Physicochim Organ, Ave FD Roosevelt 50,CP160-06, B-1050 Brussels, Belgium

来源：

CHEMICAL SCIENCE | 2017年 / 8卷 / 05期

关键词：

C-H BOND; ELECTRON-RICH HETEROCYCLES; NITROGEN NUCLEOPHILES; RADICAL ALKYLATION; GOLD CATALYSIS; SECONDARY; HALIDES; BROMIDES; LIGAND; FUNCTIONALIZATION;

D O I：

10.1039/c6sc05622a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and broadly applicable process is reported for the direct alkylation of C-H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

引用

页码：3465 / 3470

页数：6

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