Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification

被引：354
|
作者：
Xu, Wei [1 ]
Xue, Xuejia [1 ]
Li, Tianhu [2 ]
Zeng, Huaqiang [1 ]
Liu, Xiaogang [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[2] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 37期
关键词：
colorimetric detection; DNA; DNA cleavage; nanostructures; nicking endonuclease; ENHANCED RAMAN-SPECTROSCOPY; SEQUENCE-SPECIFIC DETECTION; GOLD NANOPARTICLES; MOLECULAR BEACONS; HOMOGENEOUS DETECTION; SIGNAL AMPLIFICATION; OPTICAL-PROPERTIES; LIGHT-SCATTERING; SENSITIVE DNA; RNA DETECTION;
D O I：
10.1002/anie.200901772
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
One-two punch: Single stranded DNA sequences can be detected by nicking endonuclease assisted nanoparticle amplification (see picture). The detection system offers a colorimetric detection limit of 0.5 fmol within hours for selected oligonucleotides. Detection of DNA sequences with a single base mismatch or different lengths is also demonstrated. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6849 / 6852
页数：4
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