Folic acid - nanodiamond complexes: interactions of nanodiamonds with folic acid

被引：0
作者：
Laptinskiy, Kirill A. [1 ,2 ]
Burikov, Sergey A. [1 ,2 ]
Chugreeva, Galina N. [1 ]
Dolenko, Tatiana A. [1 ,2 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Phys, 1-2 Leninskie Gory, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Skobeltsyn Inst Nucl Phys, 1-2 Leninskie Gory, Moscow 119991, Russia
来源：
SARATOV FALL MEETING 2019: OPTICAL AND NANO-TECHNOLOGIES FOR BIOLOGY AND MEDICINE, | 2020年 / 11457卷
基金：
俄罗斯科学基金会;
关键词：
nanodiamond complexes; adsorption activity; drug delivery; folic acid; CANCER; NANOCLUSTERS; ADSORPTION; PH;
D O I：
10.1117/12.2561024
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The article presents the results of a comparative analysis of the adsorption properties of detonation nanodiamonds (DNDs) with different surface functionalization (carboxyl and hydroxyl groups) with respect to folic acid (FA). A significant dependence of the adsorption activity of nanodiamonds on the type of functional surface groups was found. The amount of adsorbed FA on DNDs with hydroxyl groups is 300 times higher than the amount of FA adsorbed on DNDs with carboxyl groups, however, the bond strength of the hydroxyl groups of DND with FA is almost 300 weaker than the bond strength in the DND-COOH+FA complex. Based on the experimental results and calculations of the charge distribution of the deprotonated FA molecule, a model for the interaction of DND with FA is proposed.
引用
收藏
页数：7
相关论文
共 18 条
[1]   Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding [J].
Belletti, Barbara ;
Vaidya, Jayant S. ;
D'Andrea, Sara ;
Entschladen, Frank ;
Roncadin, Mario ;
Lovat, Francesca ;
Berton, Stefania ;
Perin, Tiziana ;
Candiani, Ezio ;
Reccanello, Sonia ;
Veronesi, Andrea ;
Canzonieri, Vincenzo ;
Trovo, Mauro G. ;
Zaenker, Kurt S. ;
Colombatti, Alfonso ;
Baldassarre, Gustavo ;
Massarut, Samuele .
CLINICAL CANCER RESEARCH, 2008, 14 (05) :1325-1332
[2]   Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy [J].
Chen, Haiyan ;
Li, Shulan ;
Li, Bowen ;
Ren, Xueyan ;
Li, Shengnan ;
Mahounga, Didel M. ;
Cui, Sisi ;
Gu, Yueqing ;
Achilefu, Samuel .
NANOSCALE, 2012, 4 (19) :6050-6064
[3]   Study of adsorption properties of functionalized nanodiamonds in aqueous solutions of metal salts using optical spectroscopy [J].
Dolenko, T. A. ;
Burikov, S. A. ;
Laptinskiy, K. A. ;
Laptinskaya, T. V. ;
Rosenholm, J. M. ;
Shiryaev, A. A. ;
Sabirov, A. R. ;
Vlasov, I. I. .
JOURNAL OF ALLOYS AND COMPOUNDS, 2014, 586 :S436-S439
[4]   Late effects of breast cancer treatment and potentials for rehabilitation [J].
Ewertz, Marianne ;
Jensen, Anders Bonde .
ACTA ONCOLOGICA, 2011, 50 (02) :187-193
[5]  
Masel R. I., 1996, PRINCIPLES ADSORPTIO
[6]   Principles of chemotherapy [J].
McKnight, JA .
CLINICAL TECHNIQUES IN SMALL ANIMAL PRACTICE, 2003, 18 (02) :67-72
[7]   Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform [J].
Mochalin, Vadym N. ;
Pentecost, Amanda ;
Li, Xue-Mei ;
Neitzel, Ioannis ;
Nelson, Matthew ;
Wei, Chongyang ;
He, Tao ;
Guo, Fang ;
Gogotsi, Yury .
MOLECULAR PHARMACEUTICS, 2013, 10 (10) :3728-3735
[8]  
Mochalin VN, 2012, NAT NANOTECHNOL, V7, P11, DOI [10.1038/NNANO.2011.209, 10.1038/nnano.2011.209]
[9]  
O'Neil M.J., 2001, MERCK INDEX ENCY CHE, P748
[10]   Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application [J].
Prabhakar, Neeraj ;
Nareoja, Tuomas ;
von Haartman, Eva ;
Sen Karaman, Didem ;
Jiang, Hua ;
Koho, Sami ;
Dolenko, Tatiana A. ;
Hanninen, Pekka E. ;
Vlasov, Denis I. ;
Ralchenko, Victor G. ;
Hosomi, Satoru ;
Vlasov, Igor I. ;
Sahlgren, Cecilia ;
Rosenholm, Jessica M. .
NANOSCALE, 2013, 5 (09) :3713-3722
12