Synthesis of new 2′-β-C-methyl related triciribine analogues as anti-HCV agents

被引：17

作者：

Smith, KL ^{[1
]}

Lai, VCH ^{[1
]}

Prigaro, BJ ^{[1
]}

Ding, YL ^{[1
]}

Gunic, E ^{[1
]}

Girardet, JL ^{[1
]}

Zhong, WD ^{[1
]}

Hong, Z ^{[1
]}

Lang, S ^{[1
]}

An, HY ^{[1
]}

机构：

[1] Valeant Pharmaceut Int, Costa Mesa, CA 92626 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2004.04.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3517 / 3520

页数：4

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