C-Terminal Fibroblast Growth Factor-23 Levels in Non-Nutritional Hypophosphatemic Rickets

Fibroblast growth factor-23 (FGF23) is central to phosphate homeostasis. The author examined if blood levels of FGF23 allow discrimination of classic hypophosphatemic ricketsfrom other causes of non-nutritional rickets with hypophosphatemia. Forty-two children (median age:102 mo) with non-nutritional rickets and hypophosphatemia were clinically classified as having distal renal tubular acidosis (RTA, n=12), Fanconi syndrome (n=8), classic hypophosphatemic rickets (n=11), vitamin D dependent rickets (n=7) and Dent disease (n=4). Median blood FGF23 (measured by C-terminal ELISA) concentrations were similar in all groups (P=0.24). These levels did not correlate with phosphate, tubular maximum for phosphate, calcium, 25-hydroxyvitamin D, creatinine, and parathormone levels. Patients with distal RTA showed variable degree of proximal tubular dysfunction that resolved following alkali supplements. Blood FGF23 levels did not satisfactorily differentiate classic hypophosphatemic rickets from other causes of hypophosphatemic rickets.