Management of gastric cancer

被引：17

作者：

Ku, Geoffrey Y. ^{[1
]}

Ilson, David H. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, New York, NY 10021 USA

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2014年 / 30卷 / 06期

关键词：

adjuvant; chemoradiation; chemotherapy; gastric cancer; preoperative; PHASE-III TRIAL; GASTROESOPHAGEAL ADENOCARCINOMA; PERIOPERATIVE CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; PLUS FLUOROURACIL; 1ST-LINE THERAPY; CISPLATIN; SURGERY; CAPECITABINE; METAANALYSIS;

D O I：

10.1097/MOG.0000000000000115

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of review Gastric cancer is an uncommon cancer in the United States but is a very common cancer globally and is endemic in East Asia. It is a virulent cancer that presents with metastatic disease in about one half of United States patients. Recent findings In this review article, we discuss palliative chemotherapy options as well as validated preoperative, perioperative and postoperative strategies for locally advanced disease, which include chemotherapy and/ or chemoradiation. Summary In the metastatic setting, there has been incremental improvement in cytotoxic chemotherapy combinations in the past 2 decades. Two targeted agents - trastuzumab and ramucirumab - are now approved. In the locally advanced setting, perioperative chemotherapy or postoperative chemotherapy or chemoradiation improves outcomes relative to surgery alone.

引用

页码：596 / 602

页数：7

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