Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

被引：304
作者：
Ahmadian, MR [1 ]
Stege, P [1 ]
Scheffzek, K [1 ]
Wittinghofer, A [1 ]
机构：
[1] MAX PLANCK INST MOL PHYSIOL,D-44139 DORTMUND,GERMANY
来源：
NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 09期
关键词：
D O I：
10.1038/nsb0997-686
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RasGAPs supply a catalytic residue, termed the arginine finger, into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.
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收藏
页码：686 / 689
页数：4
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