Effect at short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia

被引：49
|
作者：
Chao, CL [1 ]
Chien, KL [1 ]
Lee, YT [1 ]
机构：
[1] Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, Coll Med, Taipei 10016, Taiwan
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 84卷 / 11期
关键词：
D O I：
10.1016/S0002-9149(99)00575-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study showed that short-term vitamin administration effectively reduced post-methionine load homocysteine levels and thereby ameliorated endothelium-dependent flow-mediated vasodilation in 16 healthy adults. Post-methionine load homocysteine levels decreased from 22.7 +/- 3.8 to 17.0 +/- 2.1 mu mol/L (p <0.001), and flow-mediated vasodilation after methionine load increased from 8.6 +/- 3.6% to 13.8 +/- 2.9% (p <0.001) after vitamin administration.
引用
收藏
页码：1359 / +
页数：4
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