Hepatocyte growth factor region specifically activates mucin synthesis in rat stomach

被引：5
作者：
Ichikawa, T
Endoh, H
Hotta, K
Ishihara, K
机构：
[1] Kitasato Univ, Sch Med, Dept Biochem, Kanagawa 2288555, Japan
[2] Kitasato Univ, Sch Med, Dept Internal Med, Kanagawa 2288555, Japan
[3] Kitasato Univ, Sch Allied Hlth Sci, Dept Biochem, Kanagawa 2288555, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 392卷 / 1-2期
关键词：
HGF (hepatocyte growth factor); gastric mucin biosynthesis; HGF receptor; (rat);
D O I：
10.1016/S0014-2999(00)00111-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effects of hepatocyte growth factor (HGF) on mucin biosynthesis and the expression of its receptor in distinct sites and layers of rat gastric mucosa. HGF stimulated the mucin biosynthesis in the surface and gland mucus cells of corpus, but not in the antrum, without its trophic effects. The HGF-receptor mRNA expression was high in the surface and deep corpus mucosa, but low in the antrum. These results demonstrate that HGF has distinct effects on mucin biosynthesis in a specific region of rat stomach, suggesting different regulatory mechanisms underlying the mucus metabolism of distinct mucus-producing cells. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：87 / 91
页数：5
相关论文
共 14 条
[1]   CORRELATION OF QUANTITATIVE CHANGES OF GASTRIC-MUCOSAL GLYCOPROTEINS WITH ASPRIN-INDUCED GASTRIC DAMAGE IN RATS [J].
AZUUMI, Y ;
OHARA, S ;
ISHIHARA, K ;
OKABE, H ;
HOTTA, K .
GUT, 1980, 21 (06) :533-536
[2]   IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].
BOTTARO, DP ;
RUBIN, JS ;
FALETTO, DL ;
CHAN, AML ;
KMIECIK, TE ;
VANDEWOUDE, GF ;
AARONSON, SA .
SCIENCE, 1991, 251 (4995) :802-804
[3]  
EISENBERG M, 1995, BOCKUS GASTROENTEROL, V1, P561
[4]   HEPATOCYTE GROWTH-FACTOR REGION SPECIFICALLY STIMULATES GASTROINTESTINAL EPITHELIAL GROWTH IN PRIMARY CULTURE [J].
FUKAMACHI, H ;
ICHINOSE, M ;
TSUKADA, S ;
KAKEI, N ;
SUZUKI, T ;
MIKI, K ;
KUROKAWA, K ;
MASUI, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (02) :1445-1451
[5]   Distinct effects of tetragastrin, histamine, and CCh on rat gastric mucin synthesis and contribution of NO [J].
Ichikawa, T ;
Ishihara, K ;
Kusakabe, T ;
Kurihara, M ;
Kawakami, T ;
Takenaka, T ;
Saigenji, K ;
Hotta, K .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (01) :G138-G146
[6]   Simulant effect of nitric oxide generator and roxatidine on mucin biosynthesis of rat gastric oxyntic mucosa [J].
Ichikawa, T ;
Ishihara, K ;
Kusakabe, T ;
Kawakami, T ;
Hotta, K .
LIFE SCIENCES, 1999, 65 (04) :PL41-PL46
[7]   Establishment of monoclonal antibodies against carbohydrate moiety of gastric mucins distributed in the different sites and layers of rat gastric mucosa [J].
Ishihara, K ;
Kurihara, M ;
Goso, Y ;
Ota, H ;
Katsuyama, T ;
Hotta, K .
GLYCOCONJUGATE JOURNAL, 1996, 13 (05) :857-864
[8]   PARTIAL-PURIFICATION AND CHARACTERIZATION OF HEPATOCYTE GROWTH-FACTOR FROM SERUM OF HEPATECTOMIZED RATS [J].
NAKAMURA, T ;
NAWA, K ;
ICHIHARA, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (03) :1450-1459
[9]   HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR EFFECTS ON EPITHELIA - REGULATION OF INTERCELLULAR-JUNCTIONS IN TRANSFORMED AND NONTRANSFORMED CELL-LINES, BASOLATERAL POLARIZATION OF C-MET RECEPTOR IN TRANSFORMED AND NATURAL INTESTINAL EPITHELIA, AND INDUCTION OF RAPID WOUND REPAIR IN A TRANSFORMED MODEL EPITHELIUM [J].
NUSRAT, A ;
PARKOS, CA ;
BACARRA, AE ;
GODOWSKI, PJ ;
DELPARCHER, C ;
ROSEN, EM ;
MADARA, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2056-2065
[10]   Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats [J].
Schmassmann, A ;
Stettler, C ;
Poulsom, R ;
Tarasova, N ;
Hirschi, C ;
Flogerzi, B ;
Matsumoto, K ;
Nakamura, T ;
Halter, F .
GASTROENTEROLOGY, 1997, 113 (06) :1858-1872
12