The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship

被引：62

作者：

Kim, Il Young ^{[1
,2
]}

Lee, Dong Won ^{[1
,2
]}

Lee, Soo Bong ^{[1
,2
]}

Kwak, Ihm Soo ^{[1
,3
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Yangsan 626770, South Korea

[2] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan 626770, South Korea

[3] Pusan Natl Univ Hosp, Med Res Inst, Pusan 602739, South Korea

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

XANTHINE-OXIDASE INHIBITOR; GLOMERULAR HYPERTENSION; CARDIOVASCULAR-DISEASE; CELL-PROLIFERATION; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; SELECTIVE INHIBITOR; OXIDATIVE STRESS; RENAL-FUNCTION; HYPERURICEMIA;

D O I：

10.1155/2014/638732

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hyperuricemia is a common finding in chronic kidney disease due to decreased uric acid clearance. The role of uric acid as a risk factor for chronic kidney disease has been largely debated, and recent studies suggested a role of uric acid in the causation and progression of kidney fibrosis, a final common pathway in chronic kidney disease. Uric acid and xanthine oxidase may contribute to kidney fibrosis mainly by inducing inflammation, endothelial dysfunction, oxidative stress, and activation of the renin-angiotensin system. Besides, hyperuricemia induces alterations in renal hemodynamics via afferent arteriolopathy and contributes to the onset and progression of kidney fibrosis. Xanthine oxidase inhibitors may prevent kidney damage via lowering uric acid and/or inhibiting xanthine oxidase. However, there is still no sufficient evidence from interventional clinical researches supporting the causal relationship between uric acid and kidney fibrosis. The effect and role of xanthine oxidase inhibitors in preventing kidney fibrosis and chronic kidney disease progression must be further explored by performing future large scale clinical trials.

引用

页数：9

共 84 条

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