Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogens

被引:47
作者
Kim, NC
Desjardins, AE
Wu, CD
Kinghorn, AD [1 ]
机构
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[3] USDA ARS, Natl Ctr Agr Utilizat Res, Peoria, IL 61604 USA
[4] Univ Illinois, Coll Dent, Dept Periodont, Chicago, IL 60612 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 10期
关键词
D O I
10.1021/np9901579
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Four new triterpenoid glycosides were isolated from the root bark of Mussaenda macrophylla. Their structures were determined as 3-O-beta-D-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl- protobassic acid (1), 28-O-beta-D-glucopyranosyl-16 alpha-hydroxy-23-deoxyprotobassic acid (2), 3-O-beta-D-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl- 16 alpha-hydroxyprotobassic acid (3), and 3-O-([beta-D-glucopyranosyl- (1-->6)1-O-alpha-L-rhamnopyranosyl-(1-->2)-O-beta-D-glucopyranosyl-(1-->2))-O-beta-D-glucopyranosyl-(1-->3)-O-beta-D-glucopyranosyl-cycloarta-22,24-dien-27-oic acid (mussaendoside W, 4). Four known triterpenoids [3-O-acetyloleanolic acid (5), 3-O-acetyldaturadiol (6), rotundic acid (7), and 16 alpha-hydroxyprotobassic acid (8)] were also isolated. The structures of 1-4 were determined by several spectroscopic techniques including 2D NMR methods. Compounds 1-6 showed inhibitory activity against a periodontopathic bacterium, Porphyromonas gingivalis, but were inactive against the cariogenic organism, Streptococcus mutans.
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页码:1379 / 1384
页数:6
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