An isocyanide based multi-component reaction under catalyst- and solvent-free conditions for the synthesis of unsymmetrical thioureas

被引：18

作者：

Singh, Karandeep ^{[1
,2
]}

Sharma, Siddharth ^{[1
]}

机构：

[1] Mohanlal Sukhadia Univ, Dept Chem, Udaipur 313001, India

[2] Guru Nanak Dev Univ, Dept Chem, UGC Ctr Adv Studies Chem, Amritsar 143005, Punjab, India

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 03期

关键词：

Isocyanide; Multi-component reaction; Catalyst- and solvent-free conditions; Unsymmetrical thiourea; ORGANIC-SYNTHESIS; DERIVATIVES; CHEMISTRY; ISOTHIOCYANATES; THIOHYDANTOINS; DISULFIDES; SULFUR; AMINES; ANION;

D O I：

10.1016/j.tetlet.2016.11.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient method for the synthesis of thiourea derivatives by a sequential one-pot, three component reaction between aromatic isocyanides, amines, and 1,2-di-tert-butyldisulfane (DTBS) was developed and 27 different examples were synthesized in good to excellent yields. DTBS was identified as an effective sulfur surrogate without the use of both catalysts and solvents. This protocol does not employ any transition metal catalyst or special experimental setup. (C) 2016 Published by Elsevier Ltd.

引用

页码：197 / 201

页数：5

共 53 条

[31] Lithium bromide as a flexible, mild, and recyclable reagent for solvent-free Cannizzaro, Tishchenko, and Meerwein-Ponndorf-Verley reactions [J].