Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study

被引：40
作者：
van den Brandt, P. A.
Smits, K. M.
Goldbohm, R. A.
Weijenberg, M. P.
机构：
[1] Maastricht Univ, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands
[2] TNO Nutr & Food Res, NL-3700 AJ Zeist, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 03期
关键词：
colorectal cancer; cohort studies; magnesium; BMI;
D O I：
10.1038/sj.bjc.6603577
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n = 2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 ( n 58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.
引用
收藏
页码：510 / 513
页数：4
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