Organocatalytic cascade reactions based on push-pull dienamine platform: Synthesis of highly substituted anilines

被引：76
|
作者：
Ramachary, Dhevalapally B. [1 ]
Ramakumar, Kinthada [1 ]
Narayana, Vidadala V. [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 04期
关键词：
D O I：
10.1021/jo0623639
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiarylamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.
引用
收藏
页码：1458 / 1463
页数：6
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