Synthesis and pharmacological activity of betulin dinicotinate

被引：29
作者：
Flekhter, OB
Karachurina, LT
Nigmatullina, LR
Sapozhnikova, TA
Baltina, LA
Zarudii, FS
Galin, FZ
Spirikhin, LV
Tolstikov, GA
Plyasunova, OA
Pokrovskii, AG
机构：
[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Bashkortostan, Russia
[2] NPO Vector, Lab Retroviruses, Inst Mol Biol, Koltsov 633159, Novosibirsk Obl, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2002年 / 28卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
betulin dinicotinate; hepatoprotective; immunomodulatory; antiulcer anti-HIV activities; lupane triterpenoids;
D O I：
10.1023/A:1021297600187
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids.
引用
收藏
页码：494 / 500
页数：7
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