Zinc in the physiology and pathology of the CNS

被引：582
作者：
Sensi, Stefano L. [1 ,2 ,3 ]
Paoletti, Pierre [4 ]
Bush, Ashley I. [5 ,6 ]
Sekler, Israel [7 ]
机构：
[1] Univ G DAnnunzio, Dept Basic & Appl Med Sci, I-66013 Chieti, Italy
[2] Univ G DAnnunzio, Mol Neurol Unit, CeSI Ctr Excellence Aging, I-66013 Chieti, Italy
[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA
[4] Ecole Normale Super, CNRS, Neurobiol Lab, F-75005 Paris, France
[5] Mental Hlth Res Inst, Parkville, Vic 3052, Australia
[6] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
[7] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Physiol, Beer Sheva, Israel
来源：
NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 11期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
SYNAPTICALLY-RELEASED ZINC; TRANSIENT FOREBRAIN ISCHEMIA; AMYLOID-BETA OLIGOMERS; TARGETING A-BETA; ALZHEIMERS-DISEASE; INTRACELLULAR ZINC; CELL-DEATH; CORTICAL-NEURONS; NITRIC-OXIDE; ZNT-1; EXPRESSION;
D O I：
10.1038/nrn2734
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra- and intercellular signalling ion of the CNS, and hence of the neurophysiological importance of zinc-dependent pathways and the injurious effects of zinc dyshomeostasis. The development of some innovative therapeutic strategies is aimed at controlling and preventing the damaging effects of this cation in neurological conditions such as stroke and Alzheimer's disease.
引用
收藏
页码：780 / U38
页数：13
相关论文
共 153 条
  • [1] Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
    Adlard, Paul A.
    Cherny, Robert A.
    Finkelstein, David I.
    Gautier, Elisabeth
    Robb, Elysia
    Cortes, Mikhalina
    Volitakis, Irene
    Liu, Xiang
    Smith, Jeffrey P.
    Perez, Keyla
    Laughton, Katrina
    Li, Qiao-Xin
    Charman, Susan A.
    Nicolazzo, Joseph A.
    Wilkins, Simon
    Deleva, Karolina
    Lynch, Toni
    Kok, Gaik
    Ritchie, Craig W.
    Tanzi, Rudolph E.
    Cappai, Roberto
    Masters, Colin L.
    Barnham, Kevin J.
    Bush, Ashley I.
    [J]. NEURON, 2008, 59 (01) : 43 - 55
  • [2] The increase in Zinc levels and upregulation of Zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat
    Aguilar-Alonso, Patricia
    Martinez-Fong, Daniel
    Pazos-Salazar, Nidia G.
    Brambila, Eduardo
    Gonzalez-Barrios, Juan A.
    Mejorada, Alejandro
    Flores, Gonzalo
    Milian-PerezPena, Lourdes
    Rubio, Hector
    Leon-Chavez, Bertha A.
    [J]. BRAIN RESEARCH, 2008, 1200 : 89 - 98
  • [3] Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release
    Aizenman, E
    Stout, AK
    Harnett, KA
    Dineley, KE
    McLaughlin, B
    Reynolds, IJ
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 75 (05) : 1878 - 1888
  • [4] ARSLAN P, 1985, J BIOL CHEM, V260, P2719
  • [5] RELEASE OF ENDOGENOUS ZN-2+ FROM BRAIN-TISSUE DURING ACTIVITY
    ASSAF, SY
    CHUNG, SH
    [J]. NATURE, 1984, 308 (5961) : 734 - 736
  • [6] EXCITATION-TRANSCRIPTION COUPLING MEDIATED BY ZINC INFLUX THROUGH VOLTAGE-DEPENDENT CALCIUM CHANNELS
    ATAR, D
    BACKX, PH
    APPEL, MM
    GAO, WD
    MARBAN, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) : 2473 - 2477
  • [7] NONVESICULAR RELEASE OF NEUROTRANSMITTER
    ATTWELL, D
    BARBOUR, B
    SZATKOWSKI, M
    [J]. NEURON, 1993, 11 (03) : 401 - 407
  • [8] An architectural framework that may lie at the core of the postsynaptic density
    Baron, MK
    Boeckers, TM
    Vaida, B
    Faham, S
    Gingery, M
    Sawaya, MR
    Salyer, D
    Gundelfinger, ED
    Bowie, JU
    [J]. SCIENCE, 2006, 311 (5760) : 531 - 535
  • [9] Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus
    Besser, Limor
    Chorin, Ehud
    Sekler, Israel
    Silverman, William F.
    Atkin, Stan
    Russell, James T.
    Hershfinkel, Michal
    [J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (09) : 2890 - 2901
  • [10] Björkdahl C, 2005, NEUROREPORT, V16, P591
12345678910