Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines

被引：35

作者：

Xiong, Xiao-Feng ^{[1
]}

Jia, Zhi-Jun ^{[1
]}

Du, Wei ^{[1
]}

Jiang, Kun ^{[1
]}

Liu, Tian-Yu ^{[1
]}

Chen, Ying-Chun ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Key Lab Drug Targeting & Drug Delivery Syst Educ, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 45期

关键词：

DIVERSITY-ORIENTED SYNTHESIS; ASYMMETRIC ALDOL ADDITIONS; BRONSTED ACID; ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; REVERSAL; IMINES; CYCLOADDITION; DERIVATIVES; COMPLEXES;

D O I：

10.1039/b917408g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantio-and diastereoselective direct vinylogous Mannich reaction of alpha, alpha-dicyanoolefins and N-sulfonyl alkylimines has been developed by the catalysis of a new family of bifunctional organocatalysts merging chiral BINOL and 9-amino-9-deoxyepicinchona alkaloid skeletons, from which chiral beta-, delta- or gamma-amino compounds could be efficiently derived.

引用

页码：6994 / 6996

页数：3

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